Linked Life Data

PF05450.10

Source:http://linkedlifedata.com/resource/pfam/family/PF05450.10

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
family:comment
Nicastrin and presenilin are two major components of thegamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch. Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin) [1]. A region featured in this family has a fold similar to human transferrin receptor (TfR, Swiss:P02786) and a bacterial aminopeptidase (Swiss:P80561). It is implicated in the pathogenesis of Alzheimer's disease [4].
family:id
Nicastrin
family:description
Nicastrin
family:authorList
Moxon SJ
family:familyType
Family
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family:pubmed
family:protein