phosphatidylinositol-4,5-bisphosphate 3-kinase activity

"Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+)." [EC:2.7.1.153, RHEA:21295]

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

EC:2.7.1.153, KEGG:R04545, MetaCyc:2.7.1.153-RXN, RHEA:21295, Reactome:REACT_100772 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Xenopus tropicalis", Reactome:REACT_100872 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Taeniopygia guttata", Reactome:REACT_101016 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Rattus norvegicus", Reactome:REACT_101575 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Xenopus tropicalis", Reactome:REACT_102184 "PI3K produces PIP3 and other phosphatidyl inositides, Danio rerio", Reactome:REACT_102251 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Canis familiaris", Reactome:REACT_102826 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Xenopus tropicalis", Reactome:REACT_102896 "PI3K phosphorylates PIP2 to PIP3, Taeniopygia guttata", Reactome:REACT_103660 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Rattus norvegicus", Reactome:REACT_104423 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Canis familiaris", Reactome:REACT_104428 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Mus musculus", Reactome:REACT_104440 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Sus scrofa", Reactome:REACT_105498 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Mus musculus", Reactome:REACT_106690 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Taeniopygia guttata", Reactome:REACT_106935 "PI3K produces PIP3 and other phosphatidyl inositides, Mus musculus", Reactome:REACT_108698 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Danio rerio", Reactome:REACT_109561 "PI3K produces PIP3 and other phosphatidyl inositides, Xenopus tropicalis", Reactome:REACT_109902 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Sus scrofa", Reactome:REACT_110442 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Gallus gallus", Reactome:REACT_110694 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Taeniopygia guttata", Reactome:REACT_115133 "PI3K phosphorylates PIP2 to PIP3, Xenopus tropicalis", Reactome:REACT_115884 "Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFR mutants, Homo sapiens", Reactome:REACT_12561 "PI3K phosphorylates PIP2 to PIP3, Homo sapiens", Reactome:REACT_12624 "PI3K produces PIP3 and other phosphatidyl inositides, Homo sapiens", Reactome:REACT_12636 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Homo sapiens", Reactome:REACT_16877 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Homo sapiens", Reactome:REACT_19274 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Homo sapiens", Reactome:REACT_19310 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Homo sapiens", Reactome:REACT_20608 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Homo sapiens", Reactome:REACT_28751 "PI3K produces PIP3 and other phosphatidyl inositides, Drosophila melanogaster", Reactome:REACT_29081 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Danio rerio", Reactome:REACT_29317 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Mus musculus", Reactome:REACT_29324 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Taeniopygia guttata", Reactome:REACT_32230 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Rattus norvegicus", Reactome:REACT_32593 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Rattus norvegicus", Reactome:REACT_33239 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Sus scrofa", Reactome:REACT_33619 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Mus musculus", Reactome:REACT_6223 "Phosphorylation of PIP2 to PIP3 by Dp110, Drosophila melanogaster", Reactome:REACT_77031 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Xenopus tropicalis", Reactome:REACT_77523 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Bos taurus", Reactome:REACT_77937 "PI3K phosphorylates PIP2 to PIP3, Gallus gallus", Reactome:REACT_79149 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Rattus norvegicus", Reactome:REACT_80332 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Canis familiaris", Reactome:REACT_81604 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Taeniopygia guttata", Reactome:REACT_81757 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Gallus gallus", Reactome:REACT_83904 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Bos taurus", Reactome:REACT_84127 "PI3K produces PIP3 and other phosphatidyl inositides, Taeniopygia guttata", Reactome:REACT_84814 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Mus musculus", Reactome:REACT_85588 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Caenorhabditis elegans", Reactome:REACT_87888 "PI3K phosphorylates PIP2 to PIP3, Canis familiaris", Reactome:REACT_88487 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Drosophila melanogaster", Reactome:REACT_88994 "PI3K produces PIP3 and other phosphatidyl inositides, Rattus norvegicus", Reactome:REACT_90594 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Gallus gallus", Reactome:REACT_91594 "PI3K produces PIP3 and other phosphatidyl inositides, Gallus gallus", Reactome:REACT_92719 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Gallus gallus", Reactome:REACT_92772 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Canis familiaris", Reactome:REACT_93245 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Gallus gallus", Reactome:REACT_93516 "CD28 bound PI3K phosphorylates PIP2 to PIP3, Bos taurus", Reactome:REACT_93862 "PI3K phosphorylates PIP2 to PIP3, Rattus norvegicus", Reactome:REACT_94133 "PIK3 converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), Danio rerio", Reactome:REACT_94856 "PI3K phosphorylates PIP2 to PIP3, Mus musculus", Reactome:REACT_94871 "PI3K produces PIP3 and other phosphatidyl inositides, Canis familiaris", Reactome:REACT_94989 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Danio rerio", Reactome:REACT_95321 "PI3K catalyses the phosphorylation of PIP2 to PIP3, Canis familiaris", Reactome:REACT_95580 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Bos taurus", Reactome:REACT_97567 "PI3K produces PIP3 and other phosphatidyl inositides, Bos taurus", Reactome:REACT_98424 "PI3K alpha, beta, gamma convert PIP2 to PIP3, Bos taurus", Reactome:REACT_98754 "PI3K phosphorylates PIP2 to PIP3, Bos taurus", Reactome:REACT_99739 "G beta:gamma activated PI3Kgamma converts PIP2 to PIP3, Xenopus tropicalis"

phosphatidylinositol 3-kinase, class I, catalyst activity, phosphatidylinositol 3-kinase activity, class I, phosphatidylinositol 3-kinase activity, class II, type I phosphoinositide 3-kinase activity