Source:http://linkedlifedata.com/resource/geneontology/id/GO:0045857
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:go_curators, GOC:tb]
|
| skos:inScheme | |
| skos:prefLabel |
negative regulation of molecular function, epigenetic
|
| skos:altLabel |
down regulation of protein activity, epigenetic,
down-regulation of protein activity, epigenetic,
downregulation of protein activity, epigenetic,
negative regulation of protein activity, epigenetic
|
| skos:broader | |
| skos:narrowSynonym |
inhibition of protein activity, epigenetic
|