Source:http://linkedlifedata.com/resource/geneontology/id/GO:0039589
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response." [PMID:16691491, UniProtKB-KW:KW-1107, VZ:817]
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| skos:inScheme | |
| skos:prefLabel |
suppression by virus of host TAP complex
|
| skos:altLabel |
inhibition of host TAP by virus
|
| skos:notation |
VZ:817 "Inhibition of host TAP by virus"
|
| skos:note |
Viruses utilize multiple mechanisms to inhibit the TAP complex, including promoting degradation of the TAP proteins, interacting with the peptide-binding site of TAP to compete with peptide binding, and interacting with TAP to inhibit ATP binding and peptide-stimulated ATP hydrolysis.
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| skos:broader |