Source:http://linkedlifedata.com/resource/geneontology/id/GO:0034038
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+." [EC:2.5.1.46, GOC:pde, MetaCyc:2.5.1.46-RXN]
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| skos:inScheme | |
| skos:prefLabel |
deoxyhypusine synthase activity
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| skos:altLabel |
eIF-5A-deoxyhypusine synthase activity,
eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity,
spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity
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| skos:notation |
EC:2.5.1.46,
MetaCyc:2.5.1.46-RXN,
Reactome:REACT_100262 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Canis familiaris",
Reactome:REACT_100329 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Canis familiaris",
Reactome:REACT_101738 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Oryza sativa",
Reactome:REACT_102888 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Schizosaccharomyces pombe",
Reactome:REACT_104173 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Danio rerio",
Reactome:REACT_107932 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Sus scrofa",
Reactome:REACT_108065 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Xenopus tropicalis",
Reactome:REACT_110683 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Taeniopygia guttata",
Reactome:REACT_110942 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Arabidopsis thaliana",
Reactome:REACT_113251 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Caenorhabditis elegans",
Reactome:REACT_115046 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Caenorhabditis elegans",
Reactome:REACT_12481 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Homo sapiens",
Reactome:REACT_12551 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Homo sapiens",
Reactome:REACT_29295 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Schizosaccharomyces pombe",
Reactome:REACT_34429 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Dictyostelium discoideum",
Reactome:REACT_67840 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Saccharomyces cerevisiae",
Reactome:REACT_76973 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Drosophila melanogaster",
Reactome:REACT_79026 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Rattus norvegicus",
Reactome:REACT_80696 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Mus musculus",
Reactome:REACT_83693 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Taeniopygia guttata",
Reactome:REACT_83803 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Saccharomyces cerevisiae",
Reactome:REACT_84819 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Mus musculus",
Reactome:REACT_85742 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Oryza sativa",
Reactome:REACT_91359 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Arabidopsis thaliana",
Reactome:REACT_91583 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Xenopus tropicalis",
Reactome:REACT_92650 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Rattus norvegicus",
Reactome:REACT_93182 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Bos taurus",
Reactome:REACT_94750 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Danio rerio",
Reactome:REACT_94970 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Bos taurus",
Reactome:REACT_95014 "EIF5A + spermidine <=> EIF5A(Dhp) + 1,3-diaminopropane, Sus scrofa",
Reactome:REACT_95120 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Drosophila melanogaster",
Reactome:REACT_99111 "EIF5A(Dhp) + 1,3-diaminopropane <=> EIF5A + spermidine, Dictyostelium discoideum"
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| skos:note |
Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
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| skos:broader |