Source:http://linkedlifedata.com/resource/geneontology/id/GO:0030877
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]
|
| skos:inScheme | |
| skos:prefLabel |
beta-catenin destruction complex
|
| skos:altLabel |
APC-Axin-1-beta-catenin complex,
Axin-APC-beta-catenin-GSK3B complex,
beta-catenin degradation complex
|
| skos:note |
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
|
| skos:broader | |
| skos:narrowSynonym |
23S APC complex
|