Notch receptor processing

"The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688]

Notch receptor processing

Reactome:REACT_106849 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Mus musculus", Reactome:REACT_108234 "A third proteolytic cleavage releases NICD, Xenopus tropicalis", Reactome:REACT_109903 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Xenopus tropicalis", Reactome:REACT_2001 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Homo sapiens", Reactome:REACT_31981 "A third proteolytic cleavage releases NICD, Drosophila melanogaster", Reactome:REACT_33277 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Taeniopygia guttata", Reactome:REACT_691 "A third proteolytic cleavage releases NICD, Homo sapiens", Reactome:REACT_77097 "A third proteolytic cleavage releases NICD, Sus scrofa", Reactome:REACT_77321 "A third proteolytic cleavage releases NICD, Bos taurus", Reactome:REACT_79066 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Sus scrofa", Reactome:REACT_82022 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Bos taurus", Reactome:REACT_82265 "A third proteolytic cleavage releases NICD, Taeniopygia guttata", Reactome:REACT_83513 "A third proteolytic cleavage releases NICD, Canis familiaris", Reactome:REACT_88941 "A third proteolytic cleavage releases NICD, Gallus gallus", Reactome:REACT_89759 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Rattus norvegicus", Reactome:REACT_91812 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Drosophila melanogaster", Reactome:REACT_92471 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Canis familiaris", Reactome:REACT_93612 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Gallus gallus", Reactome:REACT_95551 "A third proteolytic cleavage releases NICD, Danio rerio", Reactome:REACT_96861 "A third proteolytic cleavage releases NICD, Rattus norvegicus", Reactome:REACT_98889 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor, Danio rerio", Reactome:REACT_99294 "A third proteolytic cleavage releases NICD, Mus musculus"