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"The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [CHEBI:16919, GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158]
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creatine biosynthetic process
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creatine anabolism, creatine biosynthesis, creatine formation, creatine synthesis
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