| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977]
|
| skos:inScheme | |
| skos:prefLabel |
nucleotide-excision repair
|
| skos:altLabel |
NER,
pyrimidine-dimer repair, DNA damage excision
|
| skos:notation |
Reactome:REACT_103880 "Nucleotide Excision Repair, Canis familiaris",
Reactome:REACT_103962 "Nucleotide Excision Repair, Schizosaccharomyces pombe",
Reactome:REACT_106982 "Nucleotide Excision Repair, Drosophila melanogaster",
Reactome:REACT_109142 "Nucleotide Excision Repair, Rattus norvegicus",
Reactome:REACT_110113 "Nucleotide Excision Repair, Plasmodium falciparum",
Reactome:REACT_1826 "Nucleotide Excision Repair, Homo sapiens",
Reactome:REACT_30685 "Nucleotide Excision Repair, Sus scrofa",
Reactome:REACT_31605 "Nucleotide Excision Repair, Danio rerio",
Reactome:REACT_71449 "Nucleotide Excision Repair, Gallus gallus",
Reactome:REACT_77033 "Nucleotide Excision Repair, Oryza sativa",
Reactome:REACT_79939 "Nucleotide Excision Repair, Xenopus tropicalis",
Reactome:REACT_81923 "Nucleotide Excision Repair, Taeniopygia guttata",
Reactome:REACT_84438 "Nucleotide Excision Repair, Caenorhabditis elegans",
Reactome:REACT_85405 "Nucleotide Excision Repair, Dictyostelium discoideum",
Reactome:REACT_88933 "Nucleotide Excision Repair, Saccharomyces cerevisiae",
Reactome:REACT_91101 "Nucleotide Excision Repair, Mus musculus",
Reactome:REACT_96106 "Nucleotide Excision Repair, Arabidopsis thaliana",
Reactome:REACT_98428 "Nucleotide Excision Repair, Bos taurus",
Reactome:REACT_98432 "Nucleotide Excision Repair, Mycobacterium tuberculosis"
|
| skos:note |
Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
|
| skos:broader | |
| skos:relatedSynonym |
intrastrand cross-link repair
|