GENERIC GTPase activator activity

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	skos:Concept
skos:definition	"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]
skos:inScheme	lld:geneontology
skos:prefLabel	GTPase activator activity
skos:altLabel	GAP activity
skos:notation	Reactome:REACT_100037 "Hydrolysis of Arf1-GTP to Arf1-GDP, Schizosaccharomyces pombe", Reactome:REACT_100399 "Rap1 signal termination by Rap1GAPs, Mus musculus", Reactome:REACT_100517 "TSC2 activates intrinsic GTPase activity of Rheb, Danio rerio", Reactome:REACT_101790 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Sus scrofa", Reactome:REACT_102733 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Mus musculus", Reactome:REACT_103137 "Hydrolysis of Arf1-GTP to Arf1-GDP, Rattus norvegicus", Reactome:REACT_103891 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Arabidopsis thaliana", Reactome:REACT_104735 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Xenopus tropicalis", Reactome:REACT_105046 "Hydrolysis of Arf1-GTP to Arf1-GDP, Canis familiaris", Reactome:REACT_105205 "TSC2 activates intrinsic GTPase activity of Rheb, Bos taurus", Reactome:REACT_106102 "Inactivation of Cdc42, Sus scrofa", Reactome:REACT_106107 "Inactivation of Cdc42, Caenorhabditis elegans", Reactome:REACT_106167 "Rap1 signal termination by Rap1GAPs, Caenorhabditis elegans", Reactome:REACT_107460 "TSC2 activates intrinsic GTPase activity of Rheb, Mus musculus", Reactome:REACT_107555 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Danio rerio", Reactome:REACT_109556 "TSC2 activates intrinsic GTPase activity of Rheb, Sus scrofa", Reactome:REACT_110213 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Dictyostelium discoideum", Reactome:REACT_110672 "Hydrolysis of Arf1-GTP to Arf1-GDP, Mus musculus", Reactome:REACT_110956 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Rattus norvegicus", Reactome:REACT_11107 "Hydrolysis of Arf1-GTP to Arf1-GDP, Homo sapiens", Reactome:REACT_112033 "Hydrolysis of Arf1-GTP to Arf1-GDP, Saccharomyces cerevisiae", Reactome:REACT_115083 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Xenopus tropicalis", Reactome:REACT_115497 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Xenopus tropicalis", Reactome:REACT_19117 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Homo sapiens", Reactome:REACT_19120 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Homo sapiens", Reactome:REACT_19125 "Inactivation of Cdc42, Homo sapiens", Reactome:REACT_19181 "Inactivation of R-Ras by Sema3A-Plexin-A1 GAP activity, Mus musculus", Reactome:REACT_19204 "Inactivation of Cdc42, Rattus norvegicus", Reactome:REACT_19359 "Inactivation of Rac1, Homo sapiens", Reactome:REACT_19409 "Inactivation of Rac1, Drosophila melanogaster", Reactome:REACT_21261 "TSC2 activates intrinsic GTPase activity of Rheb, Homo sapiens", Reactome:REACT_23811 "Rap1 signal termination by Rap1GAPs, Homo sapiens", Reactome:REACT_28434 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Rattus norvegicus", Reactome:REACT_29133 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Danio rerio", Reactome:REACT_29594 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Oryza sativa", Reactome:REACT_29936 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Schizosaccharomyces pombe", Reactome:REACT_30412 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Drosophila melanogaster", Reactome:REACT_30771 "Inactivation of Rac1, Mus musculus", Reactome:REACT_31216 "Inactivation of Cdc42, Gallus gallus", Reactome:REACT_31467 "TSC2 activates intrinsic GTPase activity of Rheb, Xenopus tropicalis", Reactome:REACT_32029 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Sus scrofa", Reactome:REACT_32249 "Rap1 signal termination by Rap1GAPs, Gallus gallus", Reactome:REACT_32397 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Rattus norvegicus", Reactome:REACT_32553 "Inactivation of Cdc42, Danio rerio", Reactome:REACT_32773 "Inactivation of Rac1, Bos taurus", Reactome:REACT_34038 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Canis familiaris", Reactome:REACT_39687 "Hydrolysis of Arf1-GTP to Arf1-GDP, Caenorhabditis elegans", Reactome:REACT_6328 "DRheb is inhibited by the TSC1/2 complex, Drosophila melanogaster", Reactome:REACT_77384 "Rap1 signal termination by Rap1GAPs, Canis familiaris", Reactome:REACT_77579 "Hydrolysis of Arf1-GTP to Arf1-GDP, Plasmodium falciparum", Reactome:REACT_79015 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Caenorhabditis elegans", Reactome:REACT_79166 "Inactivation of Rac1, Taeniopygia guttata", Reactome:REACT_79350 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Saccharomyces cerevisiae", Reactome:REACT_79491 "Hydrolysis of Arf1-GTP to Arf1-GDP, Taeniopygia guttata", Reactome:REACT_81264 "Rap1 signal termination by Rap1GAPs, Rattus norvegicus", Reactome:REACT_81375 "Hydrolysis of Arf1-GTP to Arf1-GDP, Xenopus tropicalis", Reactome:REACT_81710 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Canis familiaris", Reactome:REACT_82254 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Bos taurus", Reactome:REACT_82277 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Bos taurus", Reactome:REACT_83101 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Danio rerio", Reactome:REACT_83421 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Gallus gallus", Reactome:REACT_83638 "TSC2 activates intrinsic GTPase activity of Rheb, Drosophila melanogaster", Reactome:REACT_83910 "Hydrolysis of Arf1-GTP to Arf1-GDP, Danio rerio", Reactome:REACT_84528 "Inactivation of Rac1, Rattus norvegicus", Reactome:REACT_85155 "Inactivation of Cdc42, Mus musculus", Reactome:REACT_85340 "Rap1 signal termination by Rap1GAPs, Taeniopygia guttata", Reactome:REACT_85789 "Hydrolysis of Arf1-GTP to Arf1-GDP, Dictyostelium discoideum", Reactome:REACT_86052 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Sus scrofa", Reactome:REACT_86081 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Mus musculus", Reactome:REACT_87017 "Hydrolysis of Arf1-GTP to Arf1-GDP, Bos taurus", Reactome:REACT_87209 "Inactivation of Rac1, Gallus gallus", Reactome:REACT_87601 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Bos taurus", Reactome:REACT_88542 "Inactivation of Rac1, Danio rerio", Reactome:REACT_89520 "Hydrolysis of Arf1-GTP to Arf1-GDP, Drosophila melanogaster", Reactome:REACT_89620 "Rap1 signal termination by Rap1GAPs, Drosophila melanogaster", Reactome:REACT_89858 "Inactivation of Rac1, Canis familiaris", Reactome:REACT_91546 "Rap1 signal termination by Rap1GAPs, Dictyostelium discoideum", Reactome:REACT_91668 "TSC2 activates intrinsic GTPase activity of Rheb, Canis familiaris", Reactome:REACT_92264 "TSC2 activates intrinsic GTPase activity of Rheb, Gallus gallus", Reactome:REACT_92625 "Rap1 signal termination by Rap1GAPs, Xenopus tropicalis", Reactome:REACT_93021 "TSC2 activates intrinsic GTPase activity of Rheb, Taeniopygia guttata", Reactome:REACT_94710 "Rap1 signal termination by Rap1GAPs, Danio rerio", Reactome:REACT_95100 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Taeniopygia guttata", Reactome:REACT_95502 "Inactivation of Cdc42, Bos taurus", Reactome:REACT_95889 "Hydrolysis of Arf1-GTP to Arf1-GDP, Gallus gallus", Reactome:REACT_96614 "Inactivation of Rac1, Xenopus tropicalis", Reactome:REACT_96925 "Inactivation of Cdc42, Xenopus tropicalis", Reactome:REACT_97055 "Inactivation of Cdc42, Taeniopygia guttata", Reactome:REACT_97605 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Canis familiaris", Reactome:REACT_97802 "Rap1 signal termination by Rap1GAPs, Sus scrofa", Reactome:REACT_98275 "Rap1 signal termination by Rap1GAPs, Bos taurus", Reactome:REACT_9982 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Homo sapiens"
skos:broader	http://linkedlifedata.com/resource/geneontology/id/GO:0008047, http://linkedlifedata.com/resource/geneontology/id/GO:0030695

skos:definition

"Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]

skos:prefLabel

GTPase activator activity

skos:notation

Reactome:REACT_100037 "Hydrolysis of Arf1-GTP to Arf1-GDP, Schizosaccharomyces pombe", Reactome:REACT_100399 "Rap1 signal termination by Rap1GAPs, Mus musculus", Reactome:REACT_100517 "TSC2 activates intrinsic GTPase activity of Rheb, Danio rerio", Reactome:REACT_101790 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Sus scrofa", Reactome:REACT_102733 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Mus musculus", Reactome:REACT_103137 "Hydrolysis of Arf1-GTP to Arf1-GDP, Rattus norvegicus", Reactome:REACT_103891 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Arabidopsis thaliana", Reactome:REACT_104735 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Xenopus tropicalis", Reactome:REACT_105046 "Hydrolysis of Arf1-GTP to Arf1-GDP, Canis familiaris", Reactome:REACT_105205 "TSC2 activates intrinsic GTPase activity of Rheb, Bos taurus", Reactome:REACT_106102 "Inactivation of Cdc42, Sus scrofa", Reactome:REACT_106107 "Inactivation of Cdc42, Caenorhabditis elegans", Reactome:REACT_106167 "Rap1 signal termination by Rap1GAPs, Caenorhabditis elegans", Reactome:REACT_107460 "TSC2 activates intrinsic GTPase activity of Rheb, Mus musculus", Reactome:REACT_107555 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Danio rerio", Reactome:REACT_109556 "TSC2 activates intrinsic GTPase activity of Rheb, Sus scrofa", Reactome:REACT_110213 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Dictyostelium discoideum", Reactome:REACT_110672 "Hydrolysis of Arf1-GTP to Arf1-GDP, Mus musculus", Reactome:REACT_110956 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Rattus norvegicus", Reactome:REACT_11107 "Hydrolysis of Arf1-GTP to Arf1-GDP, Homo sapiens", Reactome:REACT_112033 "Hydrolysis of Arf1-GTP to Arf1-GDP, Saccharomyces cerevisiae", Reactome:REACT_115083 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Xenopus tropicalis", Reactome:REACT_115497 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Xenopus tropicalis", Reactome:REACT_19117 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Homo sapiens", Reactome:REACT_19120 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Homo sapiens", Reactome:REACT_19125 "Inactivation of Cdc42, Homo sapiens", Reactome:REACT_19181 "Inactivation of R-Ras by Sema3A-Plexin-A1 GAP activity, Mus musculus", Reactome:REACT_19204 "Inactivation of Cdc42, Rattus norvegicus", Reactome:REACT_19359 "Inactivation of Rac1, Homo sapiens", Reactome:REACT_19409 "Inactivation of Rac1, Drosophila melanogaster", Reactome:REACT_21261 "TSC2 activates intrinsic GTPase activity of Rheb, Homo sapiens", Reactome:REACT_23811 "Rap1 signal termination by Rap1GAPs, Homo sapiens", Reactome:REACT_28434 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Rattus norvegicus", Reactome:REACT_29133 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Danio rerio", Reactome:REACT_29594 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Oryza sativa", Reactome:REACT_29936 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Schizosaccharomyces pombe", Reactome:REACT_30412 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Drosophila melanogaster", Reactome:REACT_30771 "Inactivation of Rac1, Mus musculus", Reactome:REACT_31216 "Inactivation of Cdc42, Gallus gallus", Reactome:REACT_31467 "TSC2 activates intrinsic GTPase activity of Rheb, Xenopus tropicalis", Reactome:REACT_32029 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Sus scrofa", Reactome:REACT_32249 "Rap1 signal termination by Rap1GAPs, Gallus gallus", Reactome:REACT_32397 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Rattus norvegicus", Reactome:REACT_32553 "Inactivation of Cdc42, Danio rerio", Reactome:REACT_32773 "Inactivation of Rac1, Bos taurus", Reactome:REACT_34038 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Canis familiaris", Reactome:REACT_39687 "Hydrolysis of Arf1-GTP to Arf1-GDP, Caenorhabditis elegans", Reactome:REACT_6328 "DRheb is inhibited by the TSC1/2 complex, Drosophila melanogaster", Reactome:REACT_77384 "Rap1 signal termination by Rap1GAPs, Canis familiaris", Reactome:REACT_77579 "Hydrolysis of Arf1-GTP to Arf1-GDP, Plasmodium falciparum", Reactome:REACT_79015 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Caenorhabditis elegans", Reactome:REACT_79166 "Inactivation of Rac1, Taeniopygia guttata", Reactome:REACT_79350 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Saccharomyces cerevisiae", Reactome:REACT_79491 "Hydrolysis of Arf1-GTP to Arf1-GDP, Taeniopygia guttata", Reactome:REACT_81264 "Rap1 signal termination by Rap1GAPs, Rattus norvegicus", Reactome:REACT_81375 "Hydrolysis of Arf1-GTP to Arf1-GDP, Xenopus tropicalis", Reactome:REACT_81710 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Canis familiaris", Reactome:REACT_82254 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Bos taurus", Reactome:REACT_82277 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Bos taurus", Reactome:REACT_83101 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Danio rerio", Reactome:REACT_83421 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Gallus gallus", Reactome:REACT_83638 "TSC2 activates intrinsic GTPase activity of Rheb, Drosophila melanogaster", Reactome:REACT_83910 "Hydrolysis of Arf1-GTP to Arf1-GDP, Danio rerio", Reactome:REACT_84528 "Inactivation of Rac1, Rattus norvegicus", Reactome:REACT_85155 "Inactivation of Cdc42, Mus musculus", Reactome:REACT_85340 "Rap1 signal termination by Rap1GAPs, Taeniopygia guttata", Reactome:REACT_85789 "Hydrolysis of Arf1-GTP to Arf1-GDP, Dictyostelium discoideum", Reactome:REACT_86052 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity, Sus scrofa", Reactome:REACT_86081 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Mus musculus", Reactome:REACT_87017 "Hydrolysis of Arf1-GTP to Arf1-GDP, Bos taurus", Reactome:REACT_87209 "Inactivation of Rac1, Gallus gallus", Reactome:REACT_87601 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Bos taurus", Reactome:REACT_88542 "Inactivation of Rac1, Danio rerio", Reactome:REACT_89520 "Hydrolysis of Arf1-GTP to Arf1-GDP, Drosophila melanogaster", Reactome:REACT_89620 "Rap1 signal termination by Rap1GAPs, Drosophila melanogaster", Reactome:REACT_89858 "Inactivation of Rac1, Canis familiaris", Reactome:REACT_91546 "Rap1 signal termination by Rap1GAPs, Dictyostelium discoideum", Reactome:REACT_91668 "TSC2 activates intrinsic GTPase activity of Rheb, Canis familiaris", Reactome:REACT_92264 "TSC2 activates intrinsic GTPase activity of Rheb, Gallus gallus", Reactome:REACT_92625 "Rap1 signal termination by Rap1GAPs, Xenopus tropicalis", Reactome:REACT_93021 "TSC2 activates intrinsic GTPase activity of Rheb, Taeniopygia guttata", Reactome:REACT_94710 "Rap1 signal termination by Rap1GAPs, Danio rerio", Reactome:REACT_95100 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Taeniopygia guttata", Reactome:REACT_95502 "Inactivation of Cdc42, Bos taurus", Reactome:REACT_95889 "Hydrolysis of Arf1-GTP to Arf1-GDP, Gallus gallus", Reactome:REACT_96614 "Inactivation of Rac1, Xenopus tropicalis", Reactome:REACT_96925 "Inactivation of Cdc42, Xenopus tropicalis", Reactome:REACT_97055 "Inactivation of Cdc42, Taeniopygia guttata", Reactome:REACT_97605 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity, Canis familiaris", Reactome:REACT_97802 "Rap1 signal termination by Rap1GAPs, Sus scrofa", Reactome:REACT_98275 "Rap1 signal termination by Rap1GAPs, Bos taurus", Reactome:REACT_9982 "GAPs inactivate Rho GTPase:GTP by hydrolysis, Homo sapiens"