| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]
|
| skos:inScheme | |
| skos:prefLabel |
guanyl-nucleotide exchange factor activity
|
| skos:altLabel |
GDP-dissociation stimulator activity,
GDS,
GEF,
guanyl-nucleotide release factor activity,
guanyl-nucleotide releasing factor
|
| skos:notation |
Reactome:REACT_100054 "Liganded Gs-activating GPCR acts as a GEF for Gs, Gallus gallus",
Reactome:REACT_100149 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Bos taurus",
Reactome:REACT_100160 "Liganded Gi-activating GPCR acts as a GEF for Gi, Dictyostelium discoideum",
Reactome:REACT_100220 "Liganded Gs-activating GPCR acts as a GEF for Gs, Sus scrofa",
Reactome:REACT_100376 "C3G stimulates nucleotide exchange on Rap1, Bos taurus",
Reactome:REACT_100844 "Activation of Cdc42 by pVav1, Rattus norvegicus",
Reactome:REACT_100845 "Gi activation by P2Y purinoceptor 12, Gallus gallus",
Reactome:REACT_100865 "Gq activation by P2Y purinoceptor 1, Rattus norvegicus",
Reactome:REACT_101114 "Activation of Rap1 by membrane-associated GEFs, Sus scrofa",
Reactome:REACT_101120 "Liganded Gi-activating GPCR acts as a GEF for Gi, Bos taurus",
Reactome:REACT_101134 "Opsins that act as GEFs for G alpha-t, Mus musculus",
Reactome:REACT_101148 "Activation of Rap1 by membrane-associated GEFs, Rattus norvegicus",
Reactome:REACT_101201 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Xenopus tropicalis",
Reactome:REACT_101347 "Liganded Gz-activating GPCR acts as a GEF for Gz, Mus musculus",
Reactome:REACT_101383 "Gs activation by prostacyclin receptor, Danio rerio",
Reactome:REACT_101464 "Activation of Rap1 by membrane-associated GEFs, Caenorhabditis elegans",
Reactome:REACT_101601 "Activation of Rac1 by pVav1, Rattus norvegicus",
Reactome:REACT_102077 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Sus scrofa",
Reactome:REACT_102765 "Activation of Rac1 by pVav1, Gallus gallus",
Reactome:REACT_103302 "Sar1p Activation And Membrane Binding, Danio rerio",
Reactome:REACT_103339 "Liganded Gi-activating GPCR acts as a GEF for Gi, Taeniopygia guttata",
Reactome:REACT_103405 "Activation of Cdc42 by pVav1, Xenopus tropicalis",
Reactome:REACT_103624 "C3G stimulates nucleotide exchange on Rap1, Rattus norvegicus",
Reactome:REACT_103967 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Taeniopygia guttata",
Reactome:REACT_104045 "Liganded Gz-activating GPCR acts as a GEF for Gz, Bos taurus",
Reactome:REACT_104400 "p115-RhoGEF activation of Rac1, Canis familiaris",
Reactome:REACT_104431 "G13 activation by TP receptor, Rattus norvegicus",
Reactome:REACT_104640 "G13 activation by TP receptor, Danio rerio",
Reactome:REACT_104773 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Gallus gallus",
Reactome:REACT_105341 "VAV2 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans",
Reactome:REACT_105372 "Gq activation by P2Y purinoceptor 1, Xenopus tropicalis",
Reactome:REACT_105430 "Gq activation by P2Y purinoceptor 1, Danio rerio",
Reactome:REACT_105942 "Opsins that act as GEFs for G alpha-t, Danio rerio",
Reactome:REACT_106103 "Liganded Gi-activating GPCR acts as a GEF for Gi, Sus scrofa",
Reactome:REACT_106278 "Activation of Rap1 by cytosolic GEFs, Bos taurus",
Reactome:REACT_106432 "Liganded Gi-activating GPCR acts as a GEF for Gi, Gallus gallus",
Reactome:REACT_106521 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Rattus norvegicus",
Reactome:REACT_106839 "Activation of Rac1 by pVav1, Taeniopygia guttata",
Reactome:REACT_106962 "Gq activation by TP receptor, Mus musculus",
Reactome:REACT_107078 "Activation of Rac1 by pVav1, Canis familiaris",
Reactome:REACT_107457 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Xenopus tropicalis",
Reactome:REACT_108239 "Opsins that act as GEFs for G alpha-t, Bos taurus",
Reactome:REACT_108491 "VAV2 is a GEF for Rho/Rac family kinases, Taeniopygia guttata",
Reactome:REACT_108921 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Canis familiaris",
Reactome:REACT_109910 "Liganded Gz-activating GPCR acts as a GEF for Gz, Gallus gallus",
Reactome:REACT_109998 "Gi activation by P2Y purinoceptor 12, Bos taurus",
Reactome:REACT_110266 "Liganded Gs-activating GPCR acts as a GEF for Gs, Mus musculus",
Reactome:REACT_110292 "Gs activation by prostacyclin receptor, Taeniopygia guttata",
Reactome:REACT_110300 "Sar1p Activation And Membrane Binding, Oryza sativa",
Reactome:REACT_110415 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Mus musculus",
Reactome:REACT_110820 "C3G stimulates nucleotide exchange on Rap1, Gallus gallus",
Reactome:REACT_110821 "VAV3 is a GEF for Rho/Rac family kinases, Rattus norvegicus",
Reactome:REACT_111195 "Activation of RAC1, Homo sapiens",
Reactome:REACT_112168 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Danio rerio",
Reactome:REACT_112243 "Activation of RAC1, Xenopus tropicalis",
Reactome:REACT_112276 "VAV2 is a GEF for Rho/Rac family kinases, Schizosaccharomyces pombe",
Reactome:REACT_112354 "Activation of RAC1, Mus musculus",
Reactome:REACT_113007 "Activation of RAC1, Canis familiaris",
Reactome:REACT_113090 "p115-RhoGEF activation of Rac1, Caenorhabditis elegans",
Reactome:REACT_113408 "VAV2 is a GEF for Rho/Rac family kinases, Saccharomyces cerevisiae",
Reactome:REACT_113526 "Activation of Rap1 by membrane-associated GEFs, Drosophila melanogaster",
Reactome:REACT_113541 "p115-RhoGEF activation of Rac1, Xenopus tropicalis",
Reactome:REACT_113598 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Dictyostelium discoideum",
Reactome:REACT_114659 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Danio rerio",
Reactome:REACT_114904 "VAV3 is a GEF for Rho/Rac family kinases, Saccharomyces cerevisiae",
Reactome:REACT_115094 "VAV1 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans",
Reactome:REACT_115111 "VAV3 is a GEF for Rho/Rac family kinases, Schizosaccharomyces pombe",
Reactome:REACT_115210 "Activation of RAC1, Drosophila melanogaster",
Reactome:REACT_115748 "Rit is activated, Rattus norvegicus",
Reactome:REACT_12037 "C3G stimulates nucleotide exchange on Rap1, Homo sapiens",
Reactome:REACT_12071 "RIT/RIN are activated, Homo sapiens",
Reactome:REACT_12083 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Homo sapiens",
Reactome:REACT_1214 "p115-RhoGEF activation of Rac1, Homo sapiens",
Reactome:REACT_12453 "C3G stimulates nucleotide exchange on Rap1, Rattus norvegicus",
Reactome:REACT_12554 "Sar1p Activation And Membrane Binding, Homo sapiens",
Reactome:REACT_13694 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Homo sapiens",
Reactome:REACT_15291 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Homo sapiens",
Reactome:REACT_15507 "Activation of Rap1 by cytosolic GEFs, Homo sapiens",
Reactome:REACT_15538 "Liganded Gi-activating GPCR acts as a GEF for Gi, Homo sapiens",
Reactome:REACT_17008 "Liganded Gs-activating GPCR acts as a GEF for Gs, Homo sapiens",
Reactome:REACT_18309 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Homo sapiens",
Reactome:REACT_18400 "Opsins that act as GEFs for G alpha-t, Homo sapiens",
Reactome:REACT_19243 "Activation of Rac1 by pVav1, Homo sapiens",
Reactome:REACT_19286 "Activation of Cdc42 by pVav1, Homo sapiens",
Reactome:REACT_19346 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Homo sapiens",
Reactome:REACT_20507 "Gi activation by P2Y purinoceptor 12, Homo sapiens",
Reactome:REACT_20511 "Gq activation by TP receptor, Homo sapiens",
Reactome:REACT_20567 "G13 activation by TP receptor, Homo sapiens",
Reactome:REACT_20636 "Gq activation by P2Y purinoceptor 1, Homo sapiens",
Reactome:REACT_22110 "Glucagon:GCGR mediates GTP-GDP exchange, Homo sapiens",
Reactome:REACT_22134 "Activation of Gq by Muscarinic Acetylcholine Receptor M3 (mouse), Mus musculus"
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