GENERIC serine-type endopeptidase inhibitor activity

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	skos:Concept
skos:definition	"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]
skos:inScheme	lld:geneontology
skos:prefLabel	serine-type endopeptidase inhibitor activity
skos:altLabel	serine protease inhibitor activity, serine proteinase inhibitor activity
skos:notation	Reactome:REACT_104050 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Rattus norvegicus", Reactome:REACT_104247 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus", Reactome:REACT_104475 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Danio rerio", Reactome:REACT_104528 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus", Reactome:REACT_105611 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Bos taurus", Reactome:REACT_106048 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Canis familiaris", Reactome:REACT_106218 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Sus scrofa", Reactome:REACT_106511 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Mus musculus", Reactome:REACT_107595 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Xenopus tropicalis", Reactome:REACT_109088 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Bos taurus", Reactome:REACT_113222 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Xenopus tropicalis", Reactome:REACT_142 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Homo sapiens", Reactome:REACT_221 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Homo sapiens", Reactome:REACT_28910 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Rattus norvegicus", Reactome:REACT_30137 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Mus musculus", Reactome:REACT_32135 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Rattus norvegicus", Reactome:REACT_427 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Homo sapiens", Reactome:REACT_747 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Homo sapiens", Reactome:REACT_78671 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Xenopus tropicalis", Reactome:REACT_80821 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Gallus gallus", Reactome:REACT_83326 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Mus musculus", Reactome:REACT_83397 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Sus scrofa", Reactome:REACT_83721 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Danio rerio", Reactome:REACT_863 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Homo sapiens", Reactome:REACT_86945 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Bos taurus", Reactome:REACT_88697 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Canis familiaris", Reactome:REACT_89535 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Taeniopygia guttata", Reactome:REACT_90524 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Bos taurus", Reactome:REACT_91079 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Canis familiaris", Reactome:REACT_91370 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Danio rerio", Reactome:REACT_92292 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Canis familiaris", Reactome:REACT_93959 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Canis familiaris", Reactome:REACT_94815 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Bos taurus", Reactome:REACT_96330 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Mus musculus", Reactome:REACT_97070 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Mus musculus", Reactome:REACT_99122 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Danio rerio"
skos:broader	http://linkedlifedata.com/resource/geneontology/id/GO:0004866
skos:narrowSynonym	serpin activity

skos:definition

"Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]

skos:prefLabel

serine-type endopeptidase inhibitor activity

skos:notation

Reactome:REACT_104050 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Rattus norvegicus", Reactome:REACT_104247 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus", Reactome:REACT_104475 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Danio rerio", Reactome:REACT_104528 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus", Reactome:REACT_105611 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Bos taurus", Reactome:REACT_106048 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Canis familiaris", Reactome:REACT_106218 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Sus scrofa", Reactome:REACT_106511 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Mus musculus", Reactome:REACT_107595 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Xenopus tropicalis", Reactome:REACT_109088 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Bos taurus", Reactome:REACT_113222 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Xenopus tropicalis", Reactome:REACT_142 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Homo sapiens", Reactome:REACT_221 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Homo sapiens", Reactome:REACT_28910 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Rattus norvegicus", Reactome:REACT_30137 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Mus musculus", Reactome:REACT_32135 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Rattus norvegicus", Reactome:REACT_427 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Homo sapiens", Reactome:REACT_747 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Homo sapiens", Reactome:REACT_78671 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Xenopus tropicalis", Reactome:REACT_80821 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Gallus gallus", Reactome:REACT_83326 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Mus musculus", Reactome:REACT_83397 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR, Sus scrofa", Reactome:REACT_83721 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Danio rerio", Reactome:REACT_863 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Homo sapiens", Reactome:REACT_86945 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Bos taurus", Reactome:REACT_88697 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Canis familiaris", Reactome:REACT_89535 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Taeniopygia guttata", Reactome:REACT_90524 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Bos taurus", Reactome:REACT_91079 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1, Canis familiaris", Reactome:REACT_91370 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Danio rerio", Reactome:REACT_92292 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Canis familiaris", Reactome:REACT_93959 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Canis familiaris", Reactome:REACT_94815 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin, Bos taurus", Reactome:REACT_96330 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR, Mus musculus", Reactome:REACT_97070 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Mus musculus", Reactome:REACT_99122 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1, Danio rerio"

skos:narrowSynonym

serpin activity