ubiquitin-protein ligase activity

"Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407]

ubiquitin-protein ligase activity

EC:6.3.2.19, KEGG:R03876, MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN, Reactome:REACT_100004 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Canis familiaris", Reactome:REACT_100102 "Ubiquitination of stimulated EGFR (CBL:GRB2), Rattus norvegicus", Reactome:REACT_100126 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Taeniopygia guttata", Reactome:REACT_100359 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Mus musculus", Reactome:REACT_100699 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Sus scrofa", Reactome:REACT_100823 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Mus musculus", Reactome:REACT_100856 "CBL ubiquitinates Sprouty, Danio rerio", Reactome:REACT_101110 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Mus musculus", Reactome:REACT_101216 "CBL ubiquitinates Sprouty, Rattus norvegicus", Reactome:REACT_101217 "CBL binds and ubiquitinates phosphorylated Sprouty, Rattus norvegicus", Reactome:REACT_101822 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Mus musculus", Reactome:REACT_101849 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Drosophila melanogaster", Reactome:REACT_102186 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Xenopus tropicalis", Reactome:REACT_102220 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Xenopus tropicalis", Reactome:REACT_102841 "Ubiquitination of stimulated EGFR (CBL:GRB2), Bos taurus", Reactome:REACT_103261 "Autoubiquitination of phospho-COP1(Ser-387 ), Bos taurus", Reactome:REACT_103376 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Taeniopygia guttata", Reactome:REACT_103483 "Ubiquitination of PER Proteins, Gallus gallus", Reactome:REACT_103721 "CBL-mediated ubiquitination of CIN85, Rattus norvegicus", Reactome:REACT_103809 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Xenopus tropicalis", Reactome:REACT_104185 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Canis familiaris", Reactome:REACT_104518 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Taeniopygia guttata", Reactome:REACT_104803 "CBL ubiquitinates Sprouty, Canis familiaris", Reactome:REACT_104984 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Danio rerio", Reactome:REACT_104994 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Mus musculus", Reactome:REACT_105370 "Multiubiquitination of APC/C-associated Cdh1, Danio rerio", Reactome:REACT_105620 "Multiubiquitination of APC/C-associated Cdh1, Taeniopygia guttata", Reactome:REACT_106156 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Rattus norvegicus", Reactome:REACT_106407 "CBL binds and ubiquitinates phosphorylated Sprouty, Mus musculus", Reactome:REACT_106416 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Sus scrofa", Reactome:REACT_106527 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Gallus gallus", Reactome:REACT_106906 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Xenopus tropicalis", Reactome:REACT_107379 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Xenopus tropicalis", Reactome:REACT_107643 "Ubiquitination of phospho-p27/p21, Danio rerio", Reactome:REACT_107829 "Multiubiquitination of APC/C-associated Cdh1, Rattus norvegicus", Reactome:REACT_108396 "TRAF6 polyubiquitinates NRIF, Bos taurus", Reactome:REACT_108446 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Danio rerio", Reactome:REACT_108589 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Mus musculus", Reactome:REACT_108657 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Danio rerio", Reactome:REACT_109007 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Gallus gallus", Reactome:REACT_109071 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Drosophila melanogaster", Reactome:REACT_109354 "Ubiquitination of Emi1 by SCF-beta-TrCP, Rattus norvegicus", Reactome:REACT_109539 "Ubiquitination of Emi1 by SCF-beta-TrCP, Canis familiaris", Reactome:REACT_109637 "Autoubiquitination of phospho-COP1(Ser-387 ), Oryza sativa", Reactome:REACT_109798 "CBL-mediated ubiquitination of CIN85, Mus musculus", Reactome:REACT_110158 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Gallus gallus", Reactome:REACT_110535 "Autoubiquitination of phospho-COP1(Ser-387 ), Xenopus tropicalis", Reactome:REACT_110749 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Rattus norvegicus", Reactome:REACT_111089 "Ubiquitination of p130 (RBL2) by SCF (Skp2), Homo sapiens", Reactome:REACT_111141 "Phosphorylated SPRY2 is ubiquitinated by CBL, Homo sapiens", Reactome:REACT_111231 "CBL ubiquitinates FRS2 and FGFR, Homo sapiens", Reactome:REACT_112355 "Auto-ubiquitination of TRAF6, Bos taurus", Reactome:REACT_112414 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Danio rerio", Reactome:REACT_112448 "Ubiquitination of NEMO by TRAF6, Xenopus tropicalis", Reactome:REACT_112669 "CBL ubiquitinates Sprouty, Drosophila melanogaster", Reactome:REACT_113192 "CBL ubiquitinates Sprouty, Bos taurus", Reactome:REACT_113956 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Xenopus tropicalis", Reactome:REACT_114042 "Auto-ubiquitination of TRAF6, Gallus gallus", Reactome:REACT_114074 "CBL ubiquitinates Sprouty, Gallus gallus", Reactome:REACT_114376 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Oryza sativa", Reactome:REACT_114678 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Danio rerio", Reactome:REACT_115172 "Multiubiquitination of Nek2A, Dictyostelium discoideum", Reactome:REACT_115175 "Ubiquitination of NEMO by TRAF6, Bos taurus", Reactome:REACT_115543 "ISGylation of E2 conjugating enzymes, Homo sapiens", Reactome:REACT_115557 "CUL5 mediates ubiquitination of ERBB2, Homo sapiens", Reactome:REACT_115599 "RNF41 ubiquitinates activated ERBB3, Homo sapiens", Reactome:REACT_115658 "ISGylation of host protein filamin B, Homo sapiens", Reactome:REACT_115732 "Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL, Homo sapiens", Reactome:REACT_115802 "Monoubiquitination of FancD2, Gallus gallus", Reactome:REACT_115843 "ISGylation of protein phosphatase 1 beta (PP2CB), Homo sapiens", Reactome:REACT_115889 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer, Homo sapiens", Reactome:REACT_115890 "ISGylation of host proteins, Homo sapiens", Reactome:REACT_115934 "ISGylation of IRF3, Homo sapiens", Reactome:REACT_115952 "RNF41 ubiquitinates ERBB3, Homo sapiens", Reactome:REACT_115963 "Self-ubiquitination of RNF41, Homo sapiens", Reactome:REACT_115965 "ISGylation of viral protein NS1, Homo sapiens", Reactome:REACT_116015 "CHIP (STUB1) mediates ubiquitination of ERBB2, Homo sapiens", Reactome:REACT_116054 "ERBB4 ubiquitination by WWP1/ITCH, Homo sapiens", Reactome:REACT_116086 "Monoubiquitination of PCNA, Gallus gallus", Reactome:REACT_116132 "Activation of ISG15 by UBE1L E1 ligase, Homo sapiens", Reactome:REACT_12038 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Homo sapiens", Reactome:REACT_12048 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Homo sapiens", Reactome:REACT_12381 "CBL ubiquitinates Sprouty, Homo sapiens", Reactome:REACT_12432 "CBL binds and ubiquitinates phosphorylated Sprouty, Homo sapiens", Reactome:REACT_12451 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Homo sapiens", Reactome:REACT_12515 "Ubiquitination of stimulated EGFR (CBL), Homo sapiens"