GENERIC cyclin-dependent protein kinase activity

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	skos:Concept
skos:definition	"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670]
skos:inScheme	lld:geneontology
skos:prefLabel	cyclin-dependent protein kinase activity
skos:altLabel	ATP:cyclin phosphotransferase activity, CDK activity, CDK, catalytic subunit activity, Cdk-activating protein kinase activity, cdk-activating kinase activity, cyclin-dependent protein kinase, intrinsic catalyst activity
skos:notation	EC:2.7.11.22, MetaCyc:2.7.11.22-RXN, Reactome:REACT_100142 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Mus musculus", Reactome:REACT_100284 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Xenopus tropicalis", Reactome:REACT_100368 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Mus musculus", Reactome:REACT_100867 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Canis familiaris", Reactome:REACT_101084 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Rattus norvegicus", Reactome:REACT_101412 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Rattus norvegicus", Reactome:REACT_101652 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Mus musculus", Reactome:REACT_102726 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Rattus norvegicus", Reactome:REACT_102799 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Bos taurus", Reactome:REACT_103183 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Sus scrofa", Reactome:REACT_103312 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Xenopus tropicalis", Reactome:REACT_103830 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Bos taurus", Reactome:REACT_104343 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Danio rerio", Reactome:REACT_104830 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Canis familiaris", Reactome:REACT_106008 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Rattus norvegicus", Reactome:REACT_106596 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Canis familiaris", Reactome:REACT_107107 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Danio rerio", Reactome:REACT_107135 "CDK5 phosphorylates DARPP-32 on Thr75, Rattus norvegicus", Reactome:REACT_107346 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Rattus norvegicus", Reactome:REACT_107592 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Danio rerio", Reactome:REACT_108100 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Sus scrofa", Reactome:REACT_109124 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Rattus norvegicus", Reactome:REACT_109419 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Drosophila melanogaster", Reactome:REACT_109597 "CDK5 phosphorylates DARPP-32 on Thr75, Canis familiaris", Reactome:REACT_110505 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Mus musculus", Reactome:REACT_110542 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Danio rerio", Reactome:REACT_111206 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex, Homo sapiens", Reactome:REACT_111248 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex, Homo sapiens", Reactome:REACT_112082 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Xenopus tropicalis", Reactome:REACT_112868 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Xenopus tropicalis", Reactome:REACT_113042 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Saccharomyces cerevisiae", Reactome:REACT_113645 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Xenopus tropicalis", Reactome:REACT_113808 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Schizosaccharomyces pombe", Reactome:REACT_113866 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe", Reactome:REACT_115193 "CDK5 phosphorylates DARPP-32 on Thr75, Xenopus tropicalis", Reactome:REACT_115457 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae", Reactome:REACT_15365 "CDK5 phosphorylates DARPP-32 on Thr75, Homo sapiens", Reactome:REACT_15543 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Homo sapiens", Reactome:REACT_1627 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes, Homo sapiens", Reactome:REACT_1882 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Homo sapiens", Reactome:REACT_28043 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Rattus norvegicus", Reactome:REACT_28206 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Mus musculus", Reactome:REACT_28927 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Xenopus tropicalis", Reactome:REACT_29737 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Bos taurus", Reactome:REACT_30547 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Mus musculus", Reactome:REACT_30560 "Free APC/C phosphorylated by Cyclin B:Cdc2, Mus musculus", Reactome:REACT_30857 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Canis familiaris", Reactome:REACT_30946 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Taeniopygia guttata", Reactome:REACT_31143 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Arabidopsis thaliana", Reactome:REACT_32944 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Xenopus tropicalis", Reactome:REACT_33000 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Bos taurus", Reactome:REACT_33255 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Oryza sativa", Reactome:REACT_33633 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Mus musculus", Reactome:REACT_33864 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Bos taurus", Reactome:REACT_34028 "Free APC/C phosphorylated by Cyclin B:Cdc2, Danio rerio", Reactome:REACT_406 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes, Homo sapiens", Reactome:REACT_46105 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Sus scrofa", Reactome:REACT_55912 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Canis familiaris", Reactome:REACT_6338 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Homo sapiens", Reactome:REACT_6721 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Homo sapiens", Reactome:REACT_68077 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Canis familiaris", Reactome:REACT_6811 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Homo sapiens", Reactome:REACT_6891 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Homo sapiens", Reactome:REACT_6942 "Free APC/C phosphorylated by Cyclin B:Cdc2, Homo sapiens", Reactome:REACT_77008 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Mus musculus", Reactome:REACT_77473 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Bos taurus", Reactome:REACT_77863 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Rattus norvegicus", Reactome:REACT_78910 "Free APC/C phosphorylated by Cyclin B:Cdc2, Xenopus tropicalis", Reactome:REACT_80990 "Free APC/C phosphorylated by Cyclin B:Cdc2, Drosophila melanogaster", Reactome:REACT_81918 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Drosophila melanogaster", Reactome:REACT_82302 "CDK5 phosphorylates DARPP-32 on Thr75, Mus musculus", Reactome:REACT_82539 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Drosophila melanogaster", Reactome:REACT_82578 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Danio rerio", Reactome:REACT_83958 "CDK5 phosphorylates DARPP-32 on Thr75, Bos taurus", Reactome:REACT_84020 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Xenopus tropicalis", Reactome:REACT_84061 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Rattus norvegicus", Reactome:REACT_84295 "Free APC/C phosphorylated by Cyclin B:Cdc2, Rattus norvegicus", Reactome:REACT_852 "Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes, Homo sapiens", Reactome:REACT_85707 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Canis familiaris", Reactome:REACT_85853 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Rattus norvegicus", Reactome:REACT_86936 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Danio rerio", Reactome:REACT_88269 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Sus scrofa", Reactome:REACT_88622 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Bos taurus", Reactome:REACT_89028 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Canis familiaris", Reactome:REACT_89106 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Bos taurus", Reactome:REACT_89375 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Danio rerio", Reactome:REACT_89502 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Bos taurus", Reactome:REACT_8993 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Homo sapiens"

skos:definition

"Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670]

skos:prefLabel

cyclin-dependent protein kinase activity

skos:notation

EC:2.7.11.22, MetaCyc:2.7.11.22-RXN, Reactome:REACT_100142 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Mus musculus", Reactome:REACT_100284 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Xenopus tropicalis", Reactome:REACT_100368 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Mus musculus", Reactome:REACT_100867 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Canis familiaris", Reactome:REACT_101084 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Rattus norvegicus", Reactome:REACT_101412 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Rattus norvegicus", Reactome:REACT_101652 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Mus musculus", Reactome:REACT_102726 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Rattus norvegicus", Reactome:REACT_102799 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Bos taurus", Reactome:REACT_103183 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Sus scrofa", Reactome:REACT_103312 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Xenopus tropicalis", Reactome:REACT_103830 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Bos taurus", Reactome:REACT_104343 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Danio rerio", Reactome:REACT_104830 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Canis familiaris", Reactome:REACT_106008 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Rattus norvegicus", Reactome:REACT_106596 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Canis familiaris", Reactome:REACT_107107 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Danio rerio", Reactome:REACT_107135 "CDK5 phosphorylates DARPP-32 on Thr75, Rattus norvegicus", Reactome:REACT_107346 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Rattus norvegicus", Reactome:REACT_107592 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Danio rerio", Reactome:REACT_108100 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Sus scrofa", Reactome:REACT_109124 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Rattus norvegicus", Reactome:REACT_109419 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Drosophila melanogaster", Reactome:REACT_109597 "CDK5 phosphorylates DARPP-32 on Thr75, Canis familiaris", Reactome:REACT_110505 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Mus musculus", Reactome:REACT_110542 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Danio rerio", Reactome:REACT_111206 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex, Homo sapiens", Reactome:REACT_111248 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex, Homo sapiens", Reactome:REACT_112082 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Xenopus tropicalis", Reactome:REACT_112868 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Xenopus tropicalis", Reactome:REACT_113042 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Saccharomyces cerevisiae", Reactome:REACT_113645 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Xenopus tropicalis", Reactome:REACT_113808 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Schizosaccharomyces pombe", Reactome:REACT_113866 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe", Reactome:REACT_115193 "CDK5 phosphorylates DARPP-32 on Thr75, Xenopus tropicalis", Reactome:REACT_115457 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae", Reactome:REACT_15365 "CDK5 phosphorylates DARPP-32 on Thr75, Homo sapiens", Reactome:REACT_15543 "Cyclin B/Cdk1 mediate phosphorylation of NuMA, Homo sapiens", Reactome:REACT_1627 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes, Homo sapiens", Reactome:REACT_1882 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Homo sapiens", Reactome:REACT_28043 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Rattus norvegicus", Reactome:REACT_28206 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Mus musculus", Reactome:REACT_28927 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Xenopus tropicalis", Reactome:REACT_29737 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Bos taurus", Reactome:REACT_30547 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Mus musculus", Reactome:REACT_30560 "Free APC/C phosphorylated by Cyclin B:Cdc2, Mus musculus", Reactome:REACT_30857 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Canis familiaris", Reactome:REACT_30946 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Taeniopygia guttata", Reactome:REACT_31143 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Arabidopsis thaliana", Reactome:REACT_32944 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Xenopus tropicalis", Reactome:REACT_33000 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Bos taurus", Reactome:REACT_33255 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Oryza sativa", Reactome:REACT_33633 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Mus musculus", Reactome:REACT_33864 "Cyclin D:Cdk4/6 mediated phosphorylation of Rb and dissociation of phospho-Rb from the E2F1/2/3:DP-1 complexes, Bos taurus", Reactome:REACT_34028 "Free APC/C phosphorylated by Cyclin B:Cdc2, Danio rerio", Reactome:REACT_406 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes, Homo sapiens", Reactome:REACT_46105 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Sus scrofa", Reactome:REACT_55912 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Canis familiaris", Reactome:REACT_6338 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Homo sapiens", Reactome:REACT_6721 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Homo sapiens", Reactome:REACT_68077 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Canis familiaris", Reactome:REACT_6811 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Homo sapiens", Reactome:REACT_6891 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Homo sapiens", Reactome:REACT_6942 "Free APC/C phosphorylated by Cyclin B:Cdc2, Homo sapiens", Reactome:REACT_77008 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Mus musculus", Reactome:REACT_77473 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21, Bos taurus", Reactome:REACT_77863 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Rattus norvegicus", Reactome:REACT_78910 "Free APC/C phosphorylated by Cyclin B:Cdc2, Xenopus tropicalis", Reactome:REACT_80990 "Free APC/C phosphorylated by Cyclin B:Cdc2, Drosophila melanogaster", Reactome:REACT_81918 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Drosophila melanogaster", Reactome:REACT_82302 "CDK5 phosphorylates DARPP-32 on Thr75, Mus musculus", Reactome:REACT_82539 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Drosophila melanogaster", Reactome:REACT_82578 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Danio rerio", Reactome:REACT_83958 "CDK5 phosphorylates DARPP-32 on Thr75, Bos taurus", Reactome:REACT_84020 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Xenopus tropicalis", Reactome:REACT_84061 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Rattus norvegicus", Reactome:REACT_84295 "Free APC/C phosphorylated by Cyclin B:Cdc2, Rattus norvegicus", Reactome:REACT_852 "Phosphorylation of proteins involved in G2/M transition by active Cyclin B2:Cdc2 complexes, Homo sapiens", Reactome:REACT_85707 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Canis familiaris", Reactome:REACT_85853 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Rattus norvegicus", Reactome:REACT_86936 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2, Danio rerio", Reactome:REACT_88269 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21, Sus scrofa", Reactome:REACT_88622 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Bos taurus", Reactome:REACT_89028 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Canis familiaris", Reactome:REACT_89106 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Bos taurus", Reactome:REACT_89375 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160), Danio rerio", Reactome:REACT_89502 "Phosphorylation of M phase proteins by active Cyclin B1:Cdc2 complexes, Bos taurus", Reactome:REACT_8993 "Cyclin E:Cdk2-mediated phosphorylation of Rb, Homo sapiens"