serine-type endopeptidase activity

Source:http://linkedlifedata.com/resource/geneontology/id/GO:0004252

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Predicate	Object
rdf:type	skos:Concept
skos:definition	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]
skos:inScheme	lld:geneontology
skos:prefLabel	serine-type endopeptidase activity
skos:notation	Reactome:REACT_103434 "Processing of Proinsulin to Insulin, Rattus norvegicus", Reactome:REACT_104808 "Processing of Proinsulin to Insulin, Taeniopygia guttata", Reactome:REACT_15374 "Processing of Proinsulin to Insulin, Homo sapiens", Reactome:REACT_30489 "Processing of Proinsulin to Insulin, Danio rerio", Reactome:REACT_31280 "Processing of Proinsulin to Insulin, Xenopus tropicalis", Reactome:REACT_34275 "Processing of Proinsulin to Insulin, Bos taurus", Reactome:REACT_76942 "Processing of Proinsulin to Insulin, Canis familiaris", Reactome:REACT_85582 "Processing of Proinsulin to Insulin, Mus musculus", Reactome:REACT_93274 "Processing of Proinsulin to Insulin, Gallus gallus", EC:3.4.21, Reactome:REACT_100031 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Danio rerio", Reactome:REACT_100125 "Granzyme-B activates BID by cleavage, Mus musculus", Reactome:REACT_100194 "Thrombin-mediated activation of Proteinase-activated receptors, Taeniopygia guttata", Reactome:REACT_100271 "pro-factor IX -> factor IX + factor IX propeptide, Rattus norvegicus", Reactome:REACT_100321 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Rattus norvegicus", Reactome:REACT_10058 "Part of pro-beta-NGF is processed to mature beta-NGF, Homo sapiens", Reactome:REACT_100669 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Rattus norvegicus", Reactome:REACT_100764 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Gallus gallus", Reactome:REACT_100842 "pro-factor VII -> factor VII + factor VII propeptide, Canis familiaris", Reactome:REACT_100919 "Formation of alternate C5 convertase, Mus musculus", Reactome:REACT_100938 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Canis familiaris", Reactome:REACT_101008 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Rattus norvegicus", Reactome:REACT_101012 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Danio rerio", Reactome:REACT_101033 "Processing of Proglucagon to Glucagon-like Peptide-1, Rattus norvegicus", Reactome:REACT_101265 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Gallus gallus", Reactome:REACT_101293 "pro-factor IX -> factor IX + factor IX propeptide, Mus musculus", Reactome:REACT_101358 "Notch 1 precursor cleaved to form a heterodimer, Rattus norvegicus", Reactome:REACT_101408 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Bos taurus", Reactome:REACT_101486 "Granzyme-B activates BID by cleavage, Canis familiaris", Reactome:REACT_101710 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Bos taurus", Reactome:REACT_102047 "Processing of preproGLP-1 to proGLP-1, Xenopus tropicalis", Reactome:REACT_102222 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Danio rerio", Reactome:REACT_102226 "factor Va -> factor Vi, Taeniopygia guttata", Reactome:REACT_102247 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Sus scrofa", Reactome:REACT_102300 "pro-factor VII -> factor VII + factor VII propeptide, Gallus gallus", Reactome:REACT_102318 "Processing of preproGLP-1 to proGLP-1, Mus musculus", Reactome:REACT_102435 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Canis familiaris", Reactome:REACT_102450 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Bos taurus", Reactome:REACT_102555 "Cleavage of ATF6-alpha by S1P, Drosophila melanogaster", Reactome:REACT_102564 "Notch 1 precursor cleaved to form a heterodimer, Mus musculus", Reactome:REACT_102660 "Factor D cleaves C3b-bound Factor B, Danio rerio", Reactome:REACT_102717 "factor Va -> factor Vi, Bos taurus", Reactome:REACT_102762 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Mus musculus", Reactome:REACT_103193 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Taeniopygia guttata", Reactome:REACT_103297 "Extracellular processing of novel PDGFs, Gallus gallus", Reactome:REACT_103317 "protein C -> activated protein C + protein C heavy chain activation peptide, Bos taurus", Reactome:REACT_103386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Xenopus tropicalis", Reactome:REACT_103529 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Canis familiaris", Reactome:REACT_103532 "Processing of classical PDGFs, Gallus gallus", Reactome:REACT_103534 "Latent TGF-beta1 is cleaved by furin, Xenopus tropicalis", Reactome:REACT_103821 "pro-factor X -> factor X + factor X propeptide, Gallus gallus", Reactome:REACT_104063 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Sus scrofa", Reactome:REACT_104096 "Processing of preproGLP-1 to proGLP-1, Canis familiaris", Reactome:REACT_104436 "pro-factor IX -> factor IX + factor IX propeptide, Gallus gallus", Reactome:REACT_104461 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Danio rerio", Reactome:REACT_104513 "Conversion of C2 into C2a and C2b, Mus musculus", Reactome:REACT_104582 "Part of pro-beta-NGF is processed to mature beta-NGF, Sus scrofa", Reactome:REACT_104633 "factor Va -> factor Vi, Mus musculus", Reactome:REACT_104789 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Taeniopygia guttata", Reactome:REACT_104872 "Cleavage of ATF6-alpha by S1P, Gallus gallus", Reactome:REACT_104930 "pro-factor IX -> factor IX + factor IX propeptide, Sus scrofa", Reactome:REACT_105381 "Notch 1 precursor cleaved to form a heterodimer, Danio rerio", Reactome:REACT_105667 "Processing of Proglucagon to Glucagon-like Peptide-1, Canis familiaris", Reactome:REACT_105786 "Processing of Proglucagon to Glucagon-like Peptide-1, Taeniopygia guttata", Reactome:REACT_106150 "pro-GAS6 -> GAS6 + GAS6 propeptide, Sus scrofa", Reactome:REACT_106201 "Processing of proGIP to GIP, Rattus norvegicus", Reactome:REACT_106288 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Rattus norvegicus", Reactome:REACT_106360 "pro-factor IX -> factor IX + factor IX propeptide, Danio rerio", Reactome:REACT_106442 "Cleavage of the Signal Peptide of Preproghrelin, Bos taurus", Reactome:REACT_1065 "pro-prothrombin -> prothrombin + prothrombin propeptide, Homo sapiens", Reactome:REACT_106545 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Canis familiaris", Reactome:REACT_106587 "pro-prothrombin -> prothrombin + prothrombin propeptide, Mus musculus", Reactome:REACT_106621 "Notch 3 precursor cleaved to form a heterodimer, Canis familiaris", Reactome:REACT_106696 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Canis familiaris", Reactome:REACT_106726 "pro-GAS6 -> GAS6 + GAS6 propeptide, Taeniopygia guttata", Reactome:REACT_106877 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Danio rerio", Reactome:REACT_106997 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Rattus norvegicus", Reactome:REACT_107059 "pro-factor IX -> factor IX + factor IX propeptide, Canis familiaris", Reactome:REACT_1071 "factor Va -> factor Vi, Homo sapiens", Reactome:REACT_107173 "pro-protein Z -> protein Z + protein Z propeptide, Rattus norvegicus", Reactome:REACT_107386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Sus scrofa", Reactome:REACT_107456 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Sus scrofa", Reactome:REACT_107494 "Processing of preproGLP-1 to proGLP-1, Sus scrofa", Reactome:REACT_107597 "Granzyme-B activates BID by cleavage, Sus scrofa", Reactome:REACT_107831 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Gallus gallus", Reactome:REACT_107946 "pro-protein S -> protein S + protein S propeptide, Sus scrofa", Reactome:REACT_108231 "Activation of C1R, Sus scrofa", Reactome:REACT_108261 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Bos taurus", Reactome:REACT_108266 "Cleavage of ATF6-alpha by S1P, Canis familiaris", Reactome:REACT_108267 "Processing of proGIP to GIP, Canis familiaris", Reactome:REACT_108525 "pro-factor VII -> factor VII + factor VII propeptide, Danio rerio", Reactome:REACT_108824 "Extracellular processing of novel PDGFs, Canis familiaris", Reactome:REACT_108968 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Mus musculus", Reactome:REACT_109057 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Danio rerio", Reactome:REACT_109058 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Canis familiaris", Reactome:REACT_109495 "Notch 2 precursor cleaved to form a heterodimer, Drosophila melanogaster"