Source:http://linkedlifedata.com/resource/entrezgene/interaction/967-155971
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| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
CD63 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles,
Co-fractionation,
DLG1 knockdown is associated with the redistribution and colocalization of Env toward CD63 and CD82 positive vesicle-like structures,
HIV-1 Env co-localizes with CD63 in HIV-1 infected CD4+ T cells,
In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding,
Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63,
Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection
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| entrezgene:interactionSourc... |
BioGRID
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| entrezgene:keyphrase |
inhibited by,
co-localizes with,
incorporates
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