Source:http://linkedlifedata.com/resource/entrezgene/interaction/7852-155871
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10772939,
pubmed-article:11027346,
pubmed-article:12605695,
pubmed-article:14630801,
pubmed-article:15857508,
pubmed-article:16179731,
pubmed-article:16697675,
pubmed-article:18760839,
pubmed-article:19526283,
pubmed-article:20380698,
pubmed-article:20661303,
pubmed-article:21951552,
pubmed-article:9765440,
pubmed-article:9973525
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat binds to CXCR4, competes with the natural ligand of CXCR4, SDF-1alpha, and selectively inhibits the entry and replication of X4-tropic HIV-1 in peripheral blood mononuclear cells (PBMCs), indicating a role for Tat in selecting against X4 virus,
HIV-1 Tat can inhibit CXCR4-mediated functions by interfering with the chemotactic activity of SDF-1/CXCL12, an effect mediated by Tat amino acids 25-31,
HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta),
HIV-1 Tat upregulates CXCR4 expression on lymphocytes, monocytes/macrophages and erythroid cells, indicating a role for Tat in HIV-1 pathogenesis and in promoting the infectivity of HIV-1,
HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins
|
| entrezgene:keyphrase |
inhibits,
downregulates,
cooperates with,
upregulates,
binds
|