Source:http://linkedlifedata.com/resource/entrezgene/interaction/7295-155971
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| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Cleavage of the CD4 domain 2 disulfide bond (Cys130-Cys159) by thioredoxin enhances HIV-1 gp120/gp41-mediated cell-cell fusion and virus entry,
The ability of thioredoxin, a protein disulfide isomerase (PDI), to reduce the disulfide bond in CD4 is enhanced in the presence of HIV-1 gp120 and thioredoxin also reduces disulfide bonds in gp120 directly in the absence of CD4,
Thioredoxin cleaves the gp120 disulfide bond (Cys296-Cys331) in the V3 domain and the cleavage is enhanced by CD4-expressing cells
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| entrezgene:keyphrase |
modified by,
enhanced by,
cleaved by
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