Source:http://linkedlifedata.com/resource/entrezgene/interaction/6714-156110
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization,
HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner,
HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase,
High throughput screening identifies compounds targeting the Nef SH3 binding surface and that efficiently compete for Nef-SH3 interactions,
Reconstituted Complex,
The RT loop region (residues 90-108) in the Src SH3 domain binds to HIV-1 Nef, but this binding is looser than that of the Hck SH3 domain to HIV-1 Nef
|
| entrezgene:interactionSourc... |
BioGRID
|
| entrezgene:keyphrase |
interacts with,
binds,
activates
|