Source:http://linkedlifedata.com/resource/entrezgene/interaction/6598-155348
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10773452,
pubmed-article:11430827,
pubmed-article:11479624,
pubmed-article:14963118,
pubmed-article:15875659,
pubmed-article:16075307,
pubmed-article:16403635,
pubmed-article:16772295,
pubmed-article:16945155,
pubmed-article:19014595,
pubmed-article:19232540,
pubmed-article:19389610,
pubmed-article:19398554,
pubmed-article:19503603,
pubmed-article:19515827,
pubmed-article:19750561,
pubmed-article:21159874,
pubmed-article:21347347,
pubmed-article:21994574,
pubmed-article:22928108,
pubmed-article:7627549,
pubmed-article:7801128,
pubmed-article:9448295
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A cytoplasmically localized fragment of integrase interactor 1 (INI1, hSNF5; amino acids 183-294) potently inhibits HIV-1 particle production and replication,
Active INI1 is a multimer and binds to HIV-1 IN. Ile-263 is specifically required for multimerization of INI1, whereas Ile-264 and Ile-268 are involved in both multimerization and IN binding,
Binding of integrase interactor 1 (INI1, hSNF5) to HIV-1 integrase is mediated by amino acids 183-243 of INI1 and the central domain of integrase (amino acids 48-188),
HIV-1 IN and INI1/hSNF5 bind SAP18 and selectively recruit components of Sin3a-HDAC1 complex into HIV-1 virions. HIV-1 virion-associated HDAC1 is required for efficient early post-entry events,
HIV-1 Integrase E69G and K71R mutants are impaired for SNF5/Ini1 interaction, and inhibition of SNF5/Ini1 expression by RNA interference increases HIV-1 replication,
HIV-1 preintegration complexes containing HIV-1 integrase induce the cytoplasmic recruitment of integrase interactor 1 (INI1, hSNF5) and PML and associate with these cellular proteins before migrating to the nucleus,
INI1 binds to the minor groove of DNA and stimulates IN strand transfer reactions,
Inactivation of ySNF5, the yeast homolog of integrase interactor 1 (INI1, hSNF5) abolishes the lethal phenotype induced by the expression of HIV-1 integrase in yeast, suggesting an important role for INI1 in HIV-1 integration,
Ini1 interacts with HIV-1 IN.,
Integrase interactor 1 (INI1, hSNF5) binds to HIV-1 integrase and stimulates integrase DNA end joining activity,
Integrase interactor 1 (INI1, hSNF5) is incorporated into HIV-1 virions, presumably through its interaction with HIV-1 integrase,
Reconstituted Complex; Two-hybrid,
The specificity in incorporation of INI1/hSNF5 into HIV-1 virions is directly correlated with its ability to exclusively interact with HIV-1 integrase but not with other retroviral integrases such as HIV-2, SIV, HTLV-1, and MuLV IN
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| entrezgene:interactionSourc... |
BIND,
BioGRID
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| entrezgene:keyphrase |
interacts with,
inhibited by,
binds,
recruits,
stimulated by
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