Source:http://linkedlifedata.com/resource/entrezgene/interaction/6348-155871
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat downregulates MIP-1alpha expression in Jurkat T-cells by inducing MNP-1,
HIV-1 Tat enhances the NFkappaB activity and promotes the transcriptional activation of MIP-1alpha by interacting with IkappaB-alpha and p65 RelA,
HIV-1 Tat upregulates MIP-1alpha expression in microglia, MDDC, and T and B cell lines, an effect that suggests Tat plays an important role in the pathogenesis of HIV encephalitis and AIDS associated progressive multifocal leukoencephalopathy (PML),
Wild-type Tat but not Cys-22 and oxidized Tat induces CD1A-expressing monocyte-derived dendritic cells (MDDC) maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta
|
| entrezgene:keyphrase |
downregulates,
upregulates,
activates
|