Source:http://linkedlifedata.com/resource/entrezgene/interaction/60-155971
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HIV-1 gp120 upregulates the expression of actin beta in T-cell lines but downregulates the expression of actin beta in umbilical cord blood mononuclear cells,
HIV-1 gp120-CXCR4 signaling triggers cofilin activation and actin reorganization, which are important for a post entry process leading to viral nuclear localization,
HIV-1 gp41 ectodomain fragment (amino acids 550-639) induces CD44 and -actin redistribution to the membrane lipid rafts on the human brain micro vascular endothelial cells,
Inducible T-cell kinase (ITK) affects viral entry and gp120-induced actin reorganization,
Lck phosphorylates CD3zeta and the TCR-CD3 complex is recruited to a virological synapse (VS) when cells interact with gp120+ICAM-1 bilayers, leading to creation of an F-actin-depleted zone,
Syntenin-1 is recruited toward HIV-1 gp120/gp41-driven virus/cell and cell/cell contacts, associates with CD4, limits HIV-1-induced cell fusion and viral entry, and modulates gp120/gp41-triggered actin polymerization and PIP2 accumulation,
The interaction of the long cytoplasmic tail of HIV-1 gp41 with the carboxy-terminal regulatory domain of p115-RhoGEF inhibits p115-mediated actin stress fiber formation and activation of serum response factor (SRF),
Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1
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| entrezgene:keyphrase |
inhibits,
interacts with,
induces reorganization of,
relocalizes,
modulates
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