Source:http://linkedlifedata.com/resource/entrezgene/interaction/60-155871
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Affinity Capture-Western,
HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains,
In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex,
Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat,
Uptake of the HIV-1 Tat protein is regulated by arrangement of the actin cytoskeleton in epithelial cells
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| entrezgene:interactionSourc... |
BioGRID
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| entrezgene:keyphrase |
downregulates,
regulated by,
upregulates,
induces rearrangement of
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