Source:http://linkedlifedata.com/resource/entrezgene/interaction/5699-155871
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Affinity Capture-Western,
Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation,
HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function,
HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex,
HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome,
HIV-1 Tat upregulates LMP7 and MECL1 catalytic subunits of the proteasome resulting in a more efficient generation and presentation of subdominant MHC-I-binding CTL epitopes of heterologous Ags,
Tat interacts with the beta-2i subunit proprotein of the 20S proteosome.
|
| entrezgene:interactionSourc... |
BIND,
BioGRID
|
| entrezgene:keyphrase |
inhibits,
interacts with,
upregulates,
binds,
enhances
|