Source:http://linkedlifedata.com/resource/entrezgene/interaction/5605-155871
Predicate | Object |
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rdf:type | |
entrezgene:pubmed |
pubmed-article:10509564,
pubmed-article:10780709,
pubmed-article:10799874,
pubmed-article:10982368,
pubmed-article:11044099,
pubmed-article:11260070,
pubmed-article:11409852,
pubmed-article:11579140,
pubmed-article:12167619,
pubmed-article:12482669,
pubmed-article:18569454,
pubmed-article:19884766,
pubmed-article:9223324,
pubmed-article:9325171,
pubmed-article:9558095,
pubmed-article:9621077
|
entrezgene:interactant | |
entrezgene:geneRifText |
HIV-1 Tat activates mitogen-activated protein kinases ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as the activation of CREB and increased albumin permeability,
MAP2K2 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells,
Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor
|
entrezgene:keyphrase |
downregulates,
modulates,
activates
|