Statements in which the resource exists as a subject.
PredicateObject
rdf:type
entrezgene:pubmed
entrezgene:interactant
entrezgene:geneRifText
HIV-1 Tat activates mitogen-activated protein kinases ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as the activation of CREB and increased albumin permeability, MAP2K2 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells, Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor
entrezgene:keyphrase
downregulates, modulates, activates