entrezgene:geneRifText |
Furin, a subtilisin-like eukaryotic endoprotease, is able to process HIV-1 gp160/gp140 to the cleavage products gp120 and gp41 at the cleavage site with the consensus amino acid sequence Arg-X-Lys/Arg-Arg,
Interaction between gp120 C5 region and gp41 disulfide loop in unprocessed HIV-1 Env glycoprotein is required for Env processing by furin,
V38M + N43T-N44K mutations impairs gPr160 cleavage by furin
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