Source:http://linkedlifedata.com/resource/entrezgene/interaction/3838-155807
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10772949,
pubmed-article:10888660,
pubmed-article:10964507,
pubmed-article:11152524,
pubmed-article:12504543,
pubmed-article:15142377,
pubmed-article:15731250,
pubmed-article:17344301,
pubmed-article:17586317,
pubmed-article:19275582,
pubmed-article:19338763,
pubmed-article:19458171,
pubmed-article:19803398,
pubmed-article:20015032,
pubmed-article:21318276,
pubmed-article:21489275,
pubmed-article:22110766,
pubmed-article:9261351,
pubmed-article:9436978,
pubmed-article:9463369,
pubmed-article:9582382,
pubmed-article:9817747
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A small molecule hematoxylin, which suppresses Vpr-Importin alpha interaction, blocks Vpr nuclear entry in a dose-dependent manner,
Full-length Vpr interacts with RCH1 through its binding to the C-terminal domain (residues 404-529) of RCH1,
HIV-1 Vpr interacts with both karyopherin alpha 1 and alpha 2 to facilitate nuclear import of the HIV-1 preintegration complex, however conflicting reports indicate it may also be imported by other mechanisms independently of karyopherin alpha 1 and 2,
HIV-1 Vpr interacts with importin-alpha through alphaH1 (residues 17-34) and alphaH2 (residues 46-74); the interaction via alphaH1 is indispensable for the nuclear entry of Vpr, and residues 393-462 of importin-alpha promote entry of Vpr into the nucleus,
The nuclear import of Vpr is promoted by the addition of cytoplasmic extracts from macrophages but not of that from monocytes, and the nuclear import activity is lost with immunodepletion of importin alpha from the cytoplasmic extract
|
| entrezgene:keyphrase |
interacts with,
binds,
imported by
|