Source:http://linkedlifedata.com/resource/entrezgene/interaction/3586-155971
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10089566,
pubmed-article:10807185,
pubmed-article:11087201,
pubmed-article:12089333,
pubmed-article:15481145,
pubmed-article:15603899,
pubmed-article:16160188,
pubmed-article:16547227,
pubmed-article:17983270,
pubmed-article:21689404,
pubmed-article:21936714,
pubmed-article:7511078,
pubmed-article:7553888,
pubmed-article:7815507,
pubmed-article:8764000,
pubmed-article:9108403,
pubmed-article:9143942,
pubmed-article:9225992,
pubmed-article:9534962,
pubmed-article:9658081
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12,
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL1 beta,
HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells,
HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and ERK signaling pathway,
HIV-1 gp120-induced reduction of IL-12 parallels IL-10 induction and inhibits translocation of CD40 to the surface of monocytes,
HIV-1 gp41 induces IL-10 expression in human monocytes and gp41-induced IL-10 expression leads to reduced IL-2 and interferon-gamma production,
HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env,
IL-10 inhibits gp41-induced IL-6 production and reduces the expression of IL-6 mRNA,
Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5
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| entrezgene:keyphrase |
inhibits,
cooperates with,
regulated by,
upregulates,
induces release of
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