Source:http://linkedlifedata.com/resource/entrezgene/interaction/3458-155971
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10933622,
pubmed-article:12089333,
pubmed-article:12975380,
pubmed-article:15320903,
pubmed-article:15481145,
pubmed-article:15936090,
pubmed-article:16160188,
pubmed-article:17180012,
pubmed-article:17613714,
pubmed-article:17765942,
pubmed-article:18414664,
pubmed-article:18670216,
pubmed-article:1905933,
pubmed-article:22496218,
pubmed-article:22727646,
pubmed-article:2452186,
pubmed-article:7511078,
pubmed-article:7523014,
pubmed-article:7526537,
pubmed-article:7583919,
pubmed-article:7815507,
pubmed-article:7904170,
pubmed-article:7941321,
pubmed-article:8188658,
pubmed-article:8247028,
pubmed-article:8345204,
pubmed-article:8537091,
pubmed-article:8648753,
pubmed-article:8661419,
pubmed-article:8706326,
pubmed-article:8764000,
pubmed-article:9108403,
pubmed-article:9225992,
pubmed-article:9534962,
pubmed-article:9658081,
pubmed-article:9712080
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL1 beta,
Frequent IFN-gamma and TNF-alpha NK cell responses to HIV-1 gp120 are dominant during chronic HIV-1 infection,
Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves the p38 MAPK signaling pathway,
HIV-1 gp120 in the presence of IFN-gamma induces cytotoxicity of human brain micro vascular endothelial cells (HBMECs) derived from children but not from adults,
HIV-1 gp120 inhibits natural killer (NK) cell natural cytotoxicity and this inhibition also affects the production of the proinflammatory cytokine interferon-gamma (IFN-gamma); the inhibitory activity of gp120 can be prevented by coincubation with VIP,
HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2,
IFN-gamma and gp120-induced activation of Na+/H+ exchange appears to be mediated through activation of tyrosine kinase (TK), because TK inhibitors block the action of IFN-gamma and gp120,
IFN-gamma production in mononuclear leukocytes from an HIV-1-seropositive man is induced by different concentrations of a recombinant HIV-1 envelope glycoprotein gp41 and gp120 fragment,
IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells,
In the presence of HIV-1 gp120, stimulation through the CD28 pathway partially restores IL-2 and IFN-gamma production by T cell lines in response to anti-CD3 antibodies,
Induction of the receptor activator of cytokine nuclear factor kappa B ligand (RANKL) is mediated by HIV-1 gp120; the gp120-mediated induction of RANKL is blocked by interferon-gamma,
Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120,
NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57,
PWM, LPS, IFN-gamma and IL-6 can increase HIV-1 gp41 binding to human B cells,
Peptides of gp120 representing binding regions for CD4 and chemokine receptors, as well as CD4 antibody, inhibit gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs),
Pretreatment of CD4+ cells with HIV-1 gp160 significantly reduces PHA-induced secretion of IFN-gamma and IL-2 but augments IL-4 production,
Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120,
Secretion of IL-2 and IFN-gamma stimulated with anti-CD3 antibodies is inhibited by HIV-1 gp120 in T cell lines,
Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN),
Treatment of cells with HIV-1 gp120 induces the release of IFN gamma,
Treatment of human colonic epithelial cells with recombinant gamma-interferon (rlFN gamma) induces a dose-dependent inhibition of Galactosyl ceramide (GalCer) expression on the cell surface; GalCer is a receptor for HIV-1 gp120
|
| entrezgene:keyphrase |
inhibits,
downregulates,
interacts with,
inhibited by,
upregulates,
induces release of
|