Source:http://linkedlifedata.com/resource/entrezgene/interaction/27035-156110
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Both Nef membrane localization and intact SH3-binding domain are involved in NADPH oxidase activation and superoxide anion release,
HIV-1 Nef-induced blockade of superoxide release is caused by the inhibition of NADPH oxidase activities in human macrophages; this inhibition is regulated by Nef-mediated increased synthesis and release of IL-10,
Nef induces the phosphorylation and then the translocation of the cytosolic subunit of NADPH oxidase complex p47(phox) to the plasma membrane
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| entrezgene:keyphrase |
inhibits,
activates,
phosphorylates
|