Source:http://linkedlifedata.com/resource/entrezgene/interaction/2534-156110
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10544125,
pubmed-article:10642173,
pubmed-article:14965316,
pubmed-article:15078178,
pubmed-article:15638726,
pubmed-article:16454711,
pubmed-article:20012528,
pubmed-article:21738584,
pubmed-article:22422068,
pubmed-article:7588629,
pubmed-article:7859737,
pubmed-article:8681387,
pubmed-article:9351809,
pubmed-article:9778343
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Co-crystal Structure; Reconstituted Complex,
Crystal structure studies reveal the conserved PXXP sequence motif of HIV-1 Nef is part of a polyproline type II helix that is required for Nef binding to the SH3 domain of Fyn,
HIV-1 Nef binds to the SH3 domain of Fyn through its proline-rich (PXXP) motifs between amino acid residues 65 and 82; this binding enhances viral replication but not down-regulation of CD4,
The single amino acid residue number 96 in the SH3 domain of Fyn regulates its affinity and specificity in binding to HIV-1 Nef
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| entrezgene:interactionSourc... |
BioGRID
|
| entrezgene:keyphrase |
binds
|