Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/156110-6774
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| entrezgene:pubmed | |
| entrezgene:interactant | |
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Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation of STAT3,
HIV-1 Nef activates expression of phospho-Stat3, one of the downstream signaling pathways for cell proliferation,
HIV-1 Nef activates signal transducer and activator of transcription 3 (STAT3) in the granulocyte-macrophage colony-stimulating factor-independent myeloid cell line, TF-1, and in primary human macrophages,
HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner,
HIV-1 Nef induces phosphorylation of STAT3 in M2-type macrophages,
HIV-1 Nef specifically activates STAT3 in primary human monocyte-derived macrophages (MDM); Nef-dependent STAT3 activation is mediated by the release of soluble factor(s), including MIP-1alpha and IL-6,
HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes,
The expression of HIV-1 Nef in immature dendritic cells activates STAT3
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| entrezgene:keyphrase |
interacts with,
induces phosphorylation of,
upregulates,
activates
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