Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/156110-5588
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Interactions between HIV-1 Nef and PKC isozymes in Jurkat cells show that Nef interacts preferentially with PKCtheta; the interaction of Nef and PKCtheta is independent of calcium, but enhanced by phospholipid activators of PKC,
PKCtheta is a downstream effector of LCK and is recruited by HIV-1 Nef to form the Nef/LCK/PKCtheta complex, which promotes HIV transcription,
The formation of Nef/LCK/PKCtheta complex activates the ERK MAPK signaling pathway
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| entrezgene:keyphrase |
interacts with,
complexes with
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