Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/156110-5058
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10559302,
pubmed-article:10713183,
pubmed-article:11463741,
pubmed-article:11689886,
pubmed-article:12009866,
pubmed-article:12734410,
pubmed-article:15638726,
pubmed-article:16091223,
pubmed-article:18653452,
pubmed-article:19146681,
pubmed-article:20594957,
pubmed-article:21892329,
pubmed-article:7797518,
pubmed-article:8108442,
pubmed-article:8709241,
pubmed-article:8709288,
pubmed-article:8862424,
pubmed-article:8939608,
pubmed-article:9070423,
pubmed-article:9371615,
pubmed-article:9792838
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays,
HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages,
HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex,
HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques,
HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K),
The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases,
The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity,
The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity
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| entrezgene:keyphrase |
interacts with,
associates with,
activates
|