Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/156110-1436
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Nef binds Hck and induces skewed Golgi-localization of Hck, which leads to Fms maturation arrest,
HIV-1 Nef causes the FMS N-glycosylation defect and induces relocalization of the GM130 by activating the p56Hck/MEK/ERK/GRASP65 phosphorylation cascade in the Golgi,
HIV-1 Nef downregulates CSFR expression in M2-type macrophages,
HIV-1 Nef inhibits the activation of M-CSF receptor signaling by means of the activation of Hck and the subsequent induction of an aberrant molecular association between Hck and M-CSF receptor complex
|
| entrezgene:keyphrase |
inhibits,
downregulates,
disrupts,
deglycosylates
|