Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-836
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10430052,
pubmed-article:10704341,
pubmed-article:10942389,
pubmed-article:11141237,
pubmed-article:11462036,
pubmed-article:12019321,
pubmed-article:12190962,
pubmed-article:14555204,
pubmed-article:14993250,
pubmed-article:16111829,
pubmed-article:16330530,
pubmed-article:16897667,
pubmed-article:17488272,
pubmed-article:17653867,
pubmed-article:17928446,
pubmed-article:17967742,
pubmed-article:18300076,
pubmed-article:19319745,
pubmed-article:21255440,
pubmed-article:21483669,
pubmed-article:21859712,
pubmed-article:21926353,
pubmed-article:9548463
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A point mutation (V38E) in the gp41 region of HIV-1 abolishes HIV-1-mediated apoptosis by CASP3 and minimizes CD4 loss in humanized mice without altering viral replication,
Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B,
HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization,
HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53,
HIV-1 gp120/41 Envelope proteins form a complex with integrin a47 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells,
HIV-1 gp41-dependent apoptosis involves caspase-3-dependent mitochondrial depolarization and reactive oxygen species production; HIV-1 gp41-induced mitochondrial depolarization is inhibited by the protease inhibitor nelfinavir,
Inactivation of PKR has an inhibitory effect on gp120-induced caspase-3 activation,
Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax,
Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity,
Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9,
The combinatorial toxicity of cocaine and gp120 is accompanied by an increase in both caspase-3 activity and expression of the proapoptotic protein Bax in HIV-associated neuropathological disorders,
The cytolytic process that takes place between primary uninfected CD4+ T cells and HIV-1 infected or HIV-1 gp120-expressing cells requires the activity of caspases such as ICE and CPP32,
The interaction of cell-associated HIV-1 gp120 with CXCR4-expressing target cells triggers apoptotic processes by activating caspase-9 and -3,
Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9
|
| entrezgene:keyphrase |
interacts with,
upregulates,
activates
|