Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-6352
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10644351,
pubmed-article:10774549,
pubmed-article:10775626,
pubmed-article:10820198,
pubmed-article:10872839,
pubmed-article:10882583,
pubmed-article:10964543,
pubmed-article:11313374,
pubmed-article:11602715,
pubmed-article:11878903,
pubmed-article:12089333,
pubmed-article:12953261,
pubmed-article:15481145,
pubmed-article:16343773,
pubmed-article:16393999,
pubmed-article:16841089,
pubmed-article:17765942,
pubmed-article:18663025,
pubmed-article:18706447,
pubmed-article:21945445,
pubmed-article:8898753,
pubmed-article:8976200,
pubmed-article:9256481,
pubmed-article:9359702,
pubmed-article:9420238,
pubmed-article:9576751,
pubmed-article:9826729
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES,
CXCR4-tropic HIV-1 gp120 augments the expression of RANTES, IP-10, MCP-1, and LTN in peripheral blood mononuclear cells (PBMCs), while CCR5-tropic HIV-1 gp120 also induces an increase in both IP-10 and MCP-1 production,
Chemokines such as fractalkine, macrophage-derived chemokine (MDC), RANTES, and SDF-1alpha are able to block gp120-induced apoptosis of hippocampal neurons; both fractalkine and MDC activate ERK-1/2, while SDF-1alpha activates CREB,
Exposure of macrophages to purified CCR5- or CXCR4-tropic HIV-1 envelope glycoprotein gp120 induces secretion of high levels of macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, RANTES, and tumor necrosis factor alpha,
HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES,
HIV-1 gp120-mediated upregulation of CCL5 expression requires the NF-kappaB pathway in astrocytes,
HIV-1 gp41 stimulates microglial cell production of cytokines (TNF-alpha, IL-1beta, and IL-6) and chemokines (RANTES and MIP-1alpha),
NK cells exposed to CXCR4-tropic HIV-1 gp120 produce lower levels of CC chemokines RANTES, MIP-1alpha, and MIP-1beta compared with that produced from untreated NK cells,
RANTES, MIP-1beta, and anti-CD4 antibodies inhibit CCR5-dependent cell-cell fusion mediated by HIV-1 gp120 and gp41 from macrophage-tropic isolates,
RANTES, stromal derived factor-1alpha (SDF-1alpha), macrophage-derived chemokine (MDC), and their combination attenuate HIV-1 gp120-induced food and water intake decrease in rats,
The binding of HIV-1 gp120 to CCR5 and entry of macrophage-tropic HIV-1 isolates into cells is blocked by CCR5 antagonists or the chemokine RANTES, which interacts with CCR5
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| entrezgene:keyphrase |
inhibits,
downregulates,
inhibited by,
upregulates,
induces release of
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