Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-3445
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:12089333,
pubmed-article:1381203,
pubmed-article:15481145,
pubmed-article:16160188,
pubmed-article:16278001,
pubmed-article:17180012,
pubmed-article:17360657,
pubmed-article:18414664,
pubmed-article:1905933,
pubmed-article:22814248,
pubmed-article:2552026,
pubmed-article:7511078,
pubmed-article:7526537,
pubmed-article:7583919,
pubmed-article:7815507,
pubmed-article:7904170,
pubmed-article:7913356,
pubmed-article:8345204,
pubmed-article:8661419,
pubmed-article:8764000,
pubmed-article:9108403,
pubmed-article:9225992,
pubmed-article:9343822,
pubmed-article:9658081,
pubmed-article:9865497
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL1 beta,
HIV-1 gp120 inhibits CpG-A-induced secretion of IFN-a and IFN- proteins in PBMCs,
HIV-1 gp120-specific cell mediated cytotoxicity (CMC) is enhanced by IL-2 or the combination of IL-2 and IFN-alpha,
HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2,
HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells,
IFN alpha treated effector clones (gp120+CD8+ HPB-ALL/HIV) simultaneously downregulate CD8 expression and upregulate expression of both major histocompatibility antigen complex class I (MHC-I) and HIV-1 gp120/gp160,
Interaction of HIV-1 gp120 with cell-associated CD4 leads to the induction of IFN alpha; preincubation of cells with anti-CD4 or the presence of soluble CD4 during incubation inhibits IFN alpha induction,
Interferon-alpha and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120,
Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN),
TLR-9-induced IFN-alpha production is inhibited by both monomeric and trimeric HIV-1 gp120 in plasmacytoid dendritic cells (pDC),
Treatment of cells with IFN reduces HIV-1 gp120 incorporation, as well as HIV-1 envelope-mediated incorporation of ICAM-1, into virions resulting in viruses that exhibit a significantly decreased ability to become bound to CD4+ target cells
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| entrezgene:keyphrase |
inhibits,
downregulates,
interacts with,
inhibited by,
upregulates,
enhanced by,
upregulated by
|