Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-3119
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| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
A 43-amino-acid sequence between amino acids 708 and 750 in the HIV-1 gp41(TM) cytoplasmic tail is required for efficient incorporation of HLA class II proteins into virions,
Amino acid residues 42-49 in the V1 region of CD4 are involved in the interaction between HIV-1 gp120 and class II major histocompatibility complex molecules,
HIV envelope protein gp120 can specifically inhibit CD4-dependent class II MHC-restricted T cell response to Ag,
Processing of HIV-1 gp160 to gp120 and gp41 is necessary for the association of HIV-1 envelope glycoproteins with class II MHC,
Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1),
Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells
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| entrezgene:keyphrase |
inhibits,
interacts with,
upregulates,
associates with,
incorporates
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