Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-1509
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Cathepsin D cleaves HIV-1 gp120 at positions L181-Y182 (V2 domain) and E274-V275 (C2 domain), which is important for antigen processing and presentation,
Cathepsin D may induce conformational modification of HIV-1 gp120, allowing direct interaction with the CXCR4 coreceptor and enhancing HIV-1 infectivity and entry into cells,
HIV-1 Env co-localizes with cathepsin D in HIV-1 infected CD4+ T cells,
HIV-1 gp160 is identified to have a physical interaction with cathepsin D (CTSD) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses
|
| entrezgene:keyphrase |
interacts with,
co-localizes with,
modified by,
cleaved by
|