Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155971-116444
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10448428,
pubmed-article:10555109,
pubmed-article:15749123,
pubmed-article:16481105,
pubmed-article:21491143,
pubmed-article:21948112,
pubmed-article:22114277,
pubmed-article:8563977,
pubmed-article:8581564,
pubmed-article:8724036,
pubmed-article:8804048,
pubmed-article:8821747,
pubmed-article:8822372,
pubmed-article:8845955,
pubmed-article:8955056,
pubmed-article:9745929
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 clade B gp120 significantly downregulates NMDA receptor gene and protein expression and levels of glutamine compared to clade C gp120,
HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells,
HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896,
HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit,
HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor,
HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects
|
| entrezgene:keyphrase |
downregulates,
interacts with,
binds,
activates
|