Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155908-3267
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10358091,
pubmed-article:14554087,
pubmed-article:14701878,
pubmed-article:15749819,
pubmed-article:16354571,
pubmed-article:19149558,
pubmed-article:19149559,
pubmed-article:21118098,
pubmed-article:21358275,
pubmed-article:21360055,
pubmed-article:7634337,
pubmed-article:7637788,
pubmed-article:8633082,
pubmed-article:8943370
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Depletion of endogenous HIV-1 Rev binding protein (hRIP) by RNA interference results in the loss of viral replication in human cell lines and primary macrophages; virus production is restored to wild-type levels after reintroduction of hRIP protein,
hRIP is an essential cellular HIV-1 Rev cofactor; abolishing hRIP activity with a dominant-negative mutant or RNA interference causes Rev-directed mRNAs to mislocalize and aberrantly accumulate at the nuclear periphery,
hRIP/Rab is a nucleoporin like protein that binds to the activation domain of HIV-1 Rev (amino acids 75-83) and acts as a cofactor for Rev-mediated nuclear export of HIV-1 mRNA,
hRIP/Rab is known to interact with CRM1 (exportin 1) as part of its cofactor involvement with Rev-mediated nuclear export of HIV-1 mRNA
|
| entrezgene:keyphrase |
requires,
binds
|