Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-7157
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:11311202,
pubmed-article:11554765,
pubmed-article:12501250,
pubmed-article:14595650,
pubmed-article:15050687,
pubmed-article:18189286,
pubmed-article:18719392,
pubmed-article:19604078,
pubmed-article:19732026,
pubmed-article:20610713,
pubmed-article:22732402,
pubmed-article:7777531,
pubmed-article:7818536,
pubmed-article:8207805,
pubmed-article:9129988
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression,
HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells,
HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells,
HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354,
HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells,
HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells,
HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia,
HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev,
In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax,
Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1,
The p53 tetramerization domain (residues 326-355) binds directly to residues 1-35 and 47-57 in HIV-1 Tat as evidenced by using peptide mapping, fluorescence anisotropy, and NMR spectroscopy,
When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA,
Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells
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| entrezgene:keyphrase |
inhibits,
downregulates,
interacts with,
inhibited by,
cooperates with,
induces phosphorylation of,
regulated by,
upregulates,
binds,
activates,
induces acetylation of
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