Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-7082
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Exposure to Tat diminishes the expression of several tight junction proteins, including occludin, zonula occludens (ZO)-1, and ZO-2 in the caveolar fraction of human brain micro vascular endothelial cells,
HIV-1 Tat B disrupts blood-brain barrier (BBB) integrity to a greater extent compared to HIV-1 Tat C. This BBB dysfunction is associated with modulated expression of tight junction proteins zona occuldens (ZO-1) and junctional adhesion molecule (JAM)-2,
The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1,
Treatment of a brain endothelial cell line with HIV-1 Tat results in a decrease in total levels of ZO-1 but significantly upregulate ZO-1 protein expression in the nuclei
|
| entrezgene:keyphrase |
downregulates,
relocalizes,
modulates
|