Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-7057
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Thrombospondin-1 (TSP) binds to HIV-1 Tat, an interaction that can be inhibited by heparin which can bind to both TSP and Tat,
Thrombospondin-1 (TSP) prevents endothelial cell motility induced by HIV-1 Tat and inhibits angiogenic activity exerted by Tat in the Matrigel sponge model, suggesting downregulation of TSP may be permissive for development of KS-associated angiogenesis,
Thrombospondin-1 inhibits cell internalization and HIV-1 LTR transactivating activity of extracellular HIV-1 Tat, cell interaction and mitogenic activity of extracellular Tat, as well as the autocrine loop of stimulation exerted by endogenous Tat
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| entrezgene:keyphrase |
inhibited by,
binds
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