Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-6714
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Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2,
Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin (3) subunit, pp60src and recruits VEGFR2, integrin (3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes,
HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src,
HIV-1 Tat inhibits autophagy in bystander macrophages/monocytic cells through Tat-mediated activation and phosphorylation of Src-Akt signaling,
HIV-1 Tat stimulates the tyrosine phosphorylation and activation of c-Src kinase resulting in the activation of the intrinsic kinase activity of c-Src, an effect associated with Tat-induced angiogenesis and Kaposi's sarcoma,
HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner
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| entrezgene:keyphrase |
induces phosphorylation of,
upregulates,
activates
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