Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-596
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10329560,
pubmed-article:11914580,
pubmed-article:11994280,
pubmed-article:12167335,
pubmed-article:15093750,
pubmed-article:15179054,
pubmed-article:16181427,
pubmed-article:16235026,
pubmed-article:17356300,
pubmed-article:18220834,
pubmed-article:20340172,
pubmed-article:21483469,
pubmed-article:21956116,
pubmed-article:22629415,
pubmed-article:7579350,
pubmed-article:8402618,
pubmed-article:8760290,
pubmed-article:9031086
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
A fusion protein between HIV-1 Tat and a Bcl-2 construct with the loop domain deleted (TAT-Bcl-2Deltaloop) binds to neural cell and rat brain mitochondria to increase the survival of cortical neurons,
Expression of HIV-1 Tat in hematopoietic cells results in downregulation of Bcl-2 and induction of apoptosis,
HIV-1 Tat modulates BCL2 expression in neuron cells,
HIV-1 Tat upregulates Bcl-2 expression in a variety of cell types (PBMC, MDM, Jurkat, HeLa, etc.), an effect that is linked to the ability of Tat to inhibit apoptosis,
HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER)-mediated estrogen treatment,
PDGF-BB protects neurons against HIV-1 Tat and morphine-induced apoptosis by promoting Bcl2 and inhibiting Bax expression,
Tat-expressing EBV-positive B cells show downregulation of Bcl-2, and in serum starvation conditions display the Retinoblastoma (Rb) hyper-phosphorylated form, progress throughout the cell cycle, and retain the ability to grow in small clumps,
Tumor protein p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes
|
| entrezgene:keyphrase |
downregulates,
interacts with,
upregulates,
modulates,
downregulated by
|