Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-581
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| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
Expression of HIV-1 Tat in hematopoietic cells results in downregulation of Bcl-2 and upregulation of Bax, resulting in the induction of apoptosis,
HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells,
HIV-1 Tat upregulates the expression of BAX in Kaposi's sarcoma cells,
HIV-1 Tat-induced Bax activation requires the presence of either p53 or p73 transcription factor in neuronal cells,
HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER)-mediated estrogen treatment,
PDGF-BB protects neurons against HIV-1 Tat and morphine-induced apoptosis by promoting Bcl2 and inhibiting Bax expression,
Tumor protein p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes
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| entrezgene:keyphrase |
interacts with,
upregulates,
activates
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