Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-5588
| Predicate | Object |
|---|---|
| rdf:type | |
| entrezgene:pubmed |
pubmed-article:10843712,
pubmed-article:11044099,
pubmed-article:11154208,
pubmed-article:11833470,
pubmed-article:11919157,
pubmed-article:12482669,
pubmed-article:18092356,
pubmed-article:18577246,
pubmed-article:20336759,
pubmed-article:21651489,
pubmed-article:2182321,
pubmed-article:8627654,
pubmed-article:8914829,
pubmed-article:9446795,
pubmed-article:9671211
|
| entrezgene:interactant | |
| entrezgene:geneRifText |
HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1,
Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT,
Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth,
Protein kinase C phosphorylates HIV-1 Tat on serine residue 46,
Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3
|
| entrezgene:keyphrase |
cooperates with,
regulated by,
activates,
phosphorylated by
|