Source:http://linkedlifedata.com/resource/entrezgene/hivinteraction/155871-51574
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| entrezgene:pubmed | |
| entrezgene:interactant | |
| entrezgene:geneRifText |
A La-related protein, LARP7, is associated with P-TEFb, HEXIM1/2, MEPCE, and 7SK RNA in a large stable complex form. Knockdown of LARP7 decreases the steady-state level of 7SK, but increases free P-TEFb and enhances Tat-mediated transcription,
HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb,
HIV-1 Tat is identified to have a physical interaction with La ribonucleoprotein domain family, member 7 (LARP7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses,
TAR binds Tat and P-TEFb as it emerges on the nascent transcript, competitively displacing the inhibitory 7SK snRNP (HEXIM1 and LARP7) and activating the P-TEFb kinase
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| entrezgene:keyphrase |
interacts with,
complexes with,
displaces
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